TRIAMTERENE & HYDROCHLOROTHIAZIDE |
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TRIAMTERENE & HYDROCHLOROTHIAZIDE
BRAND & GENERIC NAMES
Apo-Triazide
Dyazide
Maxzide
Novotriamzide
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Diuretic (potassium-sparing)
USES
Reduces fluid retention (edema).
Reduces potassium loss.
Controls, but doesn't cure, high blood pressure.
DOSAGE & USAGE INFORMATION
How to take:
Tablet or capsule -- Swallow with liquid. If you can't swallow
whole, crumble tablet or open capsule and take with liquid or
food.
When to take:
1 dose per day--Take after breakfast.
More than 1 dose per day--Take last dose no later than 6 p.m.
If you forget a dose:
Take as soon as you remember up to 6 hours late. If more than 6
hours, wait for next scheduled dose (don't double this dose).
What drug does:
Increases urine production to eliminate sodium and water from
body while conserving potassium.
Forces sodium and water excretion, reducing body fluid.
Relaxes muscle cells of small arteries.
Reduced body fluid and relaxed arteries lower blood pressure.
Time lapse before drug works:
4 to 6 hours. May require several weeks to lower blood pressure.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Lethargy, irregular heartbeat, cramps, nausea, vomiting,
hypotension, weakness, drowsiness, weak pulse, coma.
WHAT TO DO:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
If the child is unconscious and not breathing, give mouth-to-
mouth breathing. If there is no heartbeat, use cardiac massage
and mouth-to-mouth breathing (CPR). Don't try to make the child
vomit. If you can't get help quickly, take the child to nearest
emergency facility.
See EMERGENCY INFORMATION.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
Irregular heartbeat, Discontinue. Seek
weak pulse, shortness emergency treatment.
of breath; hives, rash,
intense itching,
faintness soon after a
dose (anaphylaxis).
Common:
Mood change, Discontinue. Call
muscle cramps. doctor right away.
Numbness or tingling Continue. Call doctor
in hands or feet. when convenient.
Infrequent:
Blurred vision, Discontinue. Call
abdominal pain, doctor right away.
nausea, vomiting,
kidney stones.
Dizziness, mood Continue. Call doctor
change, headache, when convenient.
dry mouth, weakness,
tiredness, weight gain
or loss.
Rare:
Sore throat, fever, Discontinue. Call
mouth sores; doctor right away.
jaundice; rash; joint
or muscle pain; hives;
unexplained bleeding or
bruising.
Corners of mouth Continue. Call doctor
cracked, weakness. when convenient.
WARNINGS & PRECAUTIONS
Don't take if:
If you are allergic to triamterene or any thiazide diuretic
drug.
If you have had severe liver or kidney disease.
Before you start, consult your doctor:
If you have gout, diabetes, liver, pancreas or kidney disorder.
If you are allergic to any sulfa drug.
If you will have surgery within 2 months, including dental
surgery, requiring general or spinal anesthesia.
Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.
Infants & children:
Don't give to infants or young children unless prescribed and
monitored by your physician.
Prolonged use:
Potassium retention which may lead to heart-rhythm problems.
Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or
sunlamp.
Driving or hazardous activities:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't climb
ladders or work in high places. Danger increases if you
drink alcohol or take medicine affecting alertness and reflexes,
such as antihistamines, tranquilizers, sedatives, pain medicine,
narcotics and mind-altering drugs.
Discontinuing:
Don't discontinue without consulting doctor. Dose may require
gradual reduction if you have taken drug for a long time. Doses
of other drugs may also require adjustment.
Others:
Hot weather and fever may cause dehydration and drop in blood
pressure. Dose may require temporary adjustment. Weigh daily and
report any unexpected weight decreases to your doctor.
May cause rise in uric acid, leading to gout.
May cause blood-sugar rise in diabetics.
POSSIBLE INTERACTION WITH OTHER DRUGS
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| ACE inhibitors: |
Decreased blood |
| captopril, enalapril, |
pressure. |
| lisinopril (see Drugs |
| Glossary) |
| Allopurinol |
Decreased allopurinol effect. |
| Amiloride |
Dangerous retention of potassium. |
| Amphotericin B |
Increased potassium. |
| Antidepressants |
Dangerous drop in |
| (see Drugs Glossary) |
blood pressure. Avoid combination |
| |
unless under medical supervision. |
| Antihypertensives |
Increased hypertensive |
| (see Drugs Glossary) |
effect. |
| Barbiturates |
Increased hydrochlorothiazide |
| |
effect. |
| (see Drugs Glossary) |
| Beta-adrenergic |
Increased antihypertensive |
| blockers (see |
effect. Dosages of both drugs |
| Drugs Glossary) |
may require adjustment. |
| Cholestyramine |
Decreased hydrochlorothiazide |
| |
effect. |
| Cortisone drugs |
Excessive potassium loss that |
| (see Drugs Glossary) |
causes dangerous heart rhythms. |
| Digitalis |
Excessive potassium |
| preparations |
loss that causes dangerous heart |
| (see Drugs Glossary) |
rhythms. |
| Diuretics, thiazide |
Increased effect of |
| (see Drugs Glossary) |
other thiazide diuretics. |
| Indapamide |
Increased diuretic effect. |
| Indomethacin |
Possible acute renal failure. |
| Lithium |
Increased lithium effect. |
| MAO inhibitors |
Increased hydrochlorothiazide |
| (see Drugs Glossary) |
effect. |
| Nitrates |
Excessive |
| (see Drugs Glossary) |
blood-pressure drop. |
| Opiates |
Weakness and faintness when arising |
| |
from bed or chair. |
| Potassium |
Possible excessive |
| supplements |
potassium retention. |
| (see Drugs Glossary) |
Decreased potassium effect. |
| Probenecid |
Decreased probenecid effect. |
| Spironolactone |
Dangerous retention of potassium. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
| Marijuana: |
Daily use--Fainting likely. |
| Tobacco: |
Decreases drug's effectiveness. |
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