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PSORALENS

PSORALENS

BRAND & GENERIC NAMES

METHOXSALEN

Methoxsalen Lotion (Topical)
Oxsoralen
Oxsoralen-Ultra
Oxsoralen (Topical)
TRIOXSALEN
Trisoralen
UltraMOP

BASIC INFORMATION

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Repigmenting agent (psoralen)

    USES

  • Repigmenting skin affected with vitiligo (absence of skin pigment).
  • Treatment for psoriasis, when other treatments haven't helped.
  • Treatment for mycosis fungoides.

    DOSAGE & USAGE INFORMATION

    How to take: or apply:

  • Tablet or capsule--Swallow with liquid or food to lessen stomach irritation.
  • Topical--As directed by doctor. When to take: or apply: 2 to 4 hours before exposure to sunlight or sunlamp. If you forget a dose: Take as soon as you remember. Delay sun exposure for at least 2 hours after taking. What drug does: Helps pigment cells when used in conjunction with ultraviolet light.

    Time lapse before drug works:

  • For vitiligo, 6 to 9 months.
  • For psoriasis, 10 weeks or longer.
  • For tanning, 3 to 4 days. Don't take with:
  • Any other medicine which causes skin sensitivity to sun. Ask pharmacist.
  • Any other medicines, even over-the-counter drugs such as cough and cold medicines, nose drops, diet pills, laxatives or caffeine, without consulting your doctor. OVERDOSE SYMPTOMS: Blistering skin, swelling feet and legs. WHAT TO DO: Overdose unlikely to threaten life. If child takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

    POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS

    SYMPTOMS WHAT TO DO

    Life-threatening:
    None expected.
    Always:

  • Increased skin Always protect from sensitivity to sun. overexposure.
  • Increased eye Always protect with sensitivity to wrap-around sunlight. sunglasses. Infrequent: None expected. Rare: Hepatitis with jaundice, Discontinue. Call blistering and peeling. doctor right away.

    WARNINGS & PRECAUTIONS

    Don't take if:

  • You are allergic to any other psoralen.
  • You are unwilling or unable to remain under close medical supervision.

    Before you start, consult your doctor:

  • If you have heart or liver disease.
  • If you have allergy to sunlight.
  • If you have cataracts.
  • If you have albinism.
  • If you have lupus erythematosis, porphyria, chronic infection, skin cancer or peptic ulcer.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Infants & children: Don't give to infants or young children unless prescribed and monitored by your physician. Prolonged use: Increased chance of toxic effects. Skin & sunlight: Too much can burn skin. Cover skin for 24 hours before and 8 hours following treatments.

    Driving or hazardous activities:
    No age-related problems expected. Protect eyes and skin from
    bright light.
    Discontinuing:
    Skin may remain sensitive for some time after treatment stops.
    Use extra protection from sun.
    Others:

  • Use sunblock on lips.
  • Don't use just to make skin tan.

    POSSIBLE INTERACTION WITH OTHER DRUGS

    Any medicine Greatly increased
    causing sensitization likelihood of
    to sunlight, such as: extreme sensitivity
    acetohexamide, to sunlight.
    amitriptyline,
    anthralin,
    barbiturates,
    bendroflumethiazide,
    carbamazepine,
    chlordiazepoxide,
    chloroquine,
    chlorothiazide,
    chloropromazine,
    chloropropamide,
    chlortetracycline,
    chlorthalidone,
    clindamycin, coal tar
    derivatives,
    cyproheptadine,
    demeclocycline,
    desipramine,
    diethylstilbrestrol,
    diphenhydramine,
    doxepin, doxycycline,
    estrogen,
    fluphenazine, gold
    preparations, glyburide,
    griseofulvin,
    hydrochlorothiazide,
    hydroflumethiazide,
    imipramine,
    lincomycin,
    mesoridazine,
    methacycline,
    nalidixic acid,
    nortriptyline, oral
    contraceptives,
    oxyphenbutazone,
    oxytetracycline,
    perphenazine,
    phenobarbital,
    phenylbutazone,
    phenytoin,
    prochlorperazine,
    promazine,
    promethazine,
    protriptyline,
    pyrazinamide,
    sulfonamides,
    tetracycline,
    thioridazine,
    thiazide diuretics,
    tolazamide, tolbutamide,
    tranylcypromine,
    triamterene,
    trifluoperazine,
    trimeprazine,
    trimipramine,
    triprolidine.

    POSSIBLE INTERACTION WITH OTHER SUBSTANCES

    Tobacco: May cause uneven absorption of
    medicine. Avoid.

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