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METOCLOPRAMIDE

METOCLOPRAMIDE

BRAND & GENERIC NAMES

Clopra
Emex
Maxeran
Maxolon
Reclomide
Reglan

BASIC INFORMATION

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Antiemetic; dopaminergic blocker (see Drugs Glossary)

    USES

  • Relieves nausea and vomiting caused by chemotherapy and drug related postoperative factors.
  • Relieves symptoms of esophagitis and stomach swelling in people with diabetes.

    DOSAGE & USAGE INFORMATION

    How to take:
    Tablet or syrup -- Swallow with liquid or food to lessen stomach
    irritation.
    When to take:
    30 minutes before symptoms expected, up to 4 times a day.
    If you forget a dose:
    Take as soon as you remember up to 2 hours late. If more than 2
    hours, wait for next scheduled dose (don't double this dose).
    What drug does:

  • Prevents smooth muscle in stomach from relaxing.
  • Affects vomiting center in brain.

    Time lapse before drug works:
    30 to 60 minutes.
    Don't take with:
    Any other medicines, even over-the-counter drugs such as cough
    and cold medicines, nose drops, diet pills, laxatives or
    caffeine, without consulting your doctor.
    OVERDOSE
    SYMPTOMS:
    Severe drowsiness, mental confusion, trembling, seizure, coma.
    WHAT TO DO:

  • Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately.
  • If the child is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make the child vomit. If you can't get help quickly, take the child to nearest emergency facility.
  • See EMERGENCY INFORMATION.

    POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS

    SYMPTOMS WHAT TO DO

    Life-threatening:
    None expected.
    Common:

  • Drowsiness, Continue. Call doctor restlessness. when convenient.
  • Rash. Continue. Call doctor when convenient. Infrequent:
  • Wheezing, shortness Discontinue. Call of breath. doctor right away.
  • Dizziness; headache; Continue. Call doctor insomnia; tender, when convenient. swollen breasts; increased milk flow. Rare:
  • Abnormal, involuntary Discontinue. Call movements of jaw, doctor right away. lips and tongue; depression; Parkinson syndrome.
  • Constipation, diarrhea, Continue. Call doctor nausea. when convenient.

    WARNINGS & PRECAUTIONS

    Don't take if:
    You are allergic to procaine, procainamide or metoclopramide.

    Before you start, consult your doctor:

  • If you have Parkinson's disease.
  • If you have liver or kidney disease.
  • If you have epilepsy.
  • If you have bleeding from gastrointestinal tract or intestinal obstruction.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. Pregnancy: No proven harm to unborn child. Avoid if possible. Infants & children: Adverse reactions more likely to occur than in adults. Prolonged use: Adverse reactions including muscle spasms and trembling hands more likely to occur. Skin & sunlight: No age-related problems expected.

    Driving or hazardous activities:
    Don't drive or pilot aircraft until you learn how medicine
    affects you. Don't work around dangerous machinery. Don't climb
    ladders or work in high places. Danger increases if you drink
    alcohol or take medicine affecting alertness and reflexes,
    such as antihistamines, tranquilizers, sedatives,
    pain medicine, narcotics and mind-altering drugs.
    Discontinuing:
    May be unnecessary to finish medicine. Follow doctor's
    instructions.
    Others:
    No age-related problems expected.

    POSSIBLE INTERACTION WITH OTHER DRUGS

    Acetaminophen Increased absorption of
    acetaminophen.
    Anticholinergics Decreased
    (see Drugs Glossary) metoclopramide effect.
    Aspirin Increased absorption of aspirin.
    Bromocriptine Decreased bromocriptine effect.
    Butyophenone Increased chance of muscle spasm
    and trembling.
    Central nervous Excess sedation.
    system depressants
    (see Drugs Glossary)
    Digitalis preparations Decreased absorption
    (see Drugs Glossary) of digitalis.
    Ethinamate Dangerous increased effects of
    ethinamate. Avoid combining.
    Fluoxetine Increased depressant effects of
    both drugs.
    Guanfacine May increase depressant effects of
    either drug.
    Insulin Unpredictable changes in blood
    glucose. Dosages may require
    adjustment.
    Leucovorin High alcohol content of leucovorin
    may cause adverse effects.
    Levodopa Increased absorption of levodopa.
    Lithium Increased absorption of lithium.
    Loxapine May increase toxic effects of both
    drugs.
    Methyprylon Increased sedative effect, perhaps
    to dangerous level. Avoid.
    Narcotics Decreased
    (see Drugs Glossary) metoclopramide effect.
    Phenothiazines Increased chance of muscle spasm
    and trembling.
    Tetracycline Slow stomach emptying.
    Thiothixines Increased chance of
    (see Drugs Glossary) muscle spasm and trembling.

    POSSIBLE INTERACTION WITH OTHER SUBSTANCES

    Marijuana: Decreased metoclopramide effect.
    Tobacco: Decreased metoclopramide effect.

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