ESTROGEN |
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ESTROGEN
BRAND & GENERIC NAMES
Amnestrogen Femogen
C.E.S. Formatrix
Clinestrone Hormonin
Conjugated Estrogens C.S.D. Menest
Delestrogen Menotrol
DES Menrium
DIENESTROL (vaginal) Milprem
DV (vaginal) Oagen
Estinyl Oestrilin
Estomed Oestrilin (vaginal)
Estrace Ogen
Estrace (vaginal) Ogen (vaginal)
ESTRADIOL (vaginal) Ortho Dienestrol (vaginal)
Estraguard (vaginal) Piperazine Estrone Sulfate
Estrocon PMB-200nal)
ESTROGENS, CONJUGATED PMB-400
(vaginal) Premarin
ESTRONE (vaginal) Premarin (vaginal)
ESTROPIPATE (vaginal) Progens
Estrovis Stilphostrol
Evex Theogen
Feminone
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Female sex hormone
(estrogen)
USES
Treatment for symptoms of menopause and menstrual-cycle
irregularity.
Treatment for estrogen-deficiency osteoporosis (bone softening
from calcium loss).
Treatment for DES-induced cancer.
Treatment for atrophic vaginitis.
DOSAGE & USAGE INFORMATION
How to take:
Tablet or capsule--Swallow with liquid. If you can't swallow
whole, crumble tablet or open capsule and take with liquid or
food.
Vaginal cream or suppositories--Use as directed on label.
When to take:
At the same time each day.
If you forget a dose:
Take as soon as you remember up to 12 hours late. If more than
12 hours, wait for next scheduled dose (don't double this dose).
What drug does:
Restores normal estrogen level in tissues.
Time lapse before drug works:
10 to 20 days.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Nausea, vomiting, fluid retention, breast enlargement and
discomfort, abnormal vaginal bleeding.
WHAT TO DO:
Overdose unlikely to threaten life. If child takes much larger
amount than prescribed, call doctor, poison-control center or
hospital emergency room for instructions.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
None expected.
Common:
Stomach cramps. Discontinue. Call doctor right
away.
Appetite loss. Continue. Call doctor when
convenient.
Nausea; diarrhea; Continue. Tell doctor
swollen feet and at next visit.
ankles; tender,
swollen breasts.
Infrequent:
Rash, stomach or Discontinue. Call
side pain. doctor right away.
Depression, Continue. Call doctor
dizziness, headache, when convenient.
irritability, vomiting,
breast lumps.
Brown blotches, Continue. Tell doctor
hair loss, vaginal at next visit.
discharge or bleeding,
changes in sex drive.
Rare:
Jaundice, hypercalcemia Discontinue. Call
in breast cancer, doctor right away.
intolerance of contact
lenses.
WARNINGS & PRECAUTIONS
Don't take if:
You are allergic to any estrogen-containing drugs.
You have impaired liver function.
You have had blood clots, stroke or heart attack.
You have unexplained vaginal bleeding.
Before you start, consult your doctor:
If you have had cancer of breast or reproductive organs,
fibrocystic breast disease, fibroid tumors of the uterus or
endometriosis.
If you have had migraine headaches, epilepsy or porphyria.
If you have diabetes, high blood pressure, asthma, congestive
heart failure, kidney disease or gallstones.
If you plan to become pregnant within 3 months.
Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.
Infants & children:
Don't give to infants or young children unless prescribed and
monitored by your physician.
Prolonged use:
Increased growth of fibroid tumors of uterus. Possible
association with cancer of uterus.
Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or
sunlamp.
Driving or hazardous activities:
No age-related problems expected.
Discontinuing:
You may need to discontinue estrogens periodically. Consult
your doctor.
Others:
In rare instances, may cause blood clot in lung, brain or leg.
Symptoms are sudden severe headache, coordination loss, vision
change, chest pain, breathing difficulty, slurred speech, pain
in legs or groin. Seek emergency treatment immediately.
Carefully read the paper called "Information for the Patient"
that was given to you with your prescription. If you lose it,
ask your pharmacist for a copy.
POSSIBLE INTERACTION WITH OTHER DRUGS
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| Anticoagulants (oral, |
Decreased |
| see Drugs Glossary) |
anticoagulant effect. |
| Anticonvulsants |
Decreased estrogen |
| (see Drugs Glossary) |
effect. |
| Antidepressants, |
Increased toxicity of |
| tricyclic (TCA, |
antidepressants. |
| see Drugs Glossary) |
| Antidiabetics (oral, |
Unpredictable |
| see Drugs Glossary) |
increase or decrease in blood |
| |
sugar. |
| Carbamazepine |
Decreased estrogen effect. |
| Clofibrate |
Decreased clofibrate effect. |
| Guanfacine |
May decrease antihypertensive |
| |
effects of guanfacine. |
| Insulin |
Possible decreased insulin effect. |
| |
May require dosage adjustment. |
| Meprobamate |
Increased estrogen effect. |
| Phenobarbital |
Decreased estrogen effect. |
| Primidone |
Decreased estrogen effect. |
| Rifampin |
Decreased estrogen effect. |
| Thyroid hormones |
Decreased thyroid effect. |
| Vitamin C |
Possible increased estrogen effect. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
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| Tobacco: |
Increased risk of blood clots |
| |
leading to stroke or heart attack. |
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