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DIURETICS, LOOP

DIURETICS, LOOP

BRAND & GENERIC NAMES

Apo-Furosemide
BUMETANIDE
Bumex
Edecrin
ETHACRYNIC ACID
FUROSEMIDE
Furoside
Lasix
Lasix Special
Neo-Renal
Novosemide
SK-Furosemide
Uritol

BASIC INFORMATION

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Diuretic, antihypertensive

    USES

  • Lowers high blood pressure.
  • Decreases fluid retention.

    DOSAGE & USAGE INFORMATION

    How to take:
    Tablet or liquid -- Swallow with liquid. If you can't swallow
    whole, crumble tablet and take with liquid or food.
    When to take:

  • 1 dose a day--Take after breakfast.
  • More than 1 dose a day--Take last dose no later than 6 p.m. unless otherwise directed. If you forget a dose:
  • 1 dose a day--Take as soon as you remember up to 12 hours late. If more than 12 hours, wait for next scheduled dose (don't double this dose).
  • More than 1 dose a day--Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Increases elimination of sodium and water from body. Decreased body fluid reduces blood pressure.

    Time lapse before drug works:
    1 hour to increase water loss. Requires 2 to 3 weeks to lower
    blood pressure.
    Don't take with:
    Any other medicines, even over-the-counter drugs such as cough
    and cold medicines, nose drops, diet pills, laxatives or
    caffeine, without consulting your doctor.
    OVERDOSE
    SYMPTOMS:
    Weakness, lethargy, dizziness, confusion, nausea, vomiting, leg-
    muscle cramps, thirst, stupor, deep sleep, weak and rapid pulse,
    cardiac arrest.
    WHAT TO DO:

  • Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY INFORMATION.

    POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS

    SYMPTOMS WHAT TO DO

    Life-threatening:
    None expected.
    Common:
    Dizziness. Continue. Call doctor when
    convenient.
    Infrequent:
    Mood change, fatigue, Discontinue. Call
    appetite loss, diarrhea, doctor right away.
    irregular heartbeat,
    muscle cramps,
    weakness, abdominal
    pain, low blood pressure.
    Rare:
    Rash or hives, yellow Discontinue. Call
    vision, ringing in ears, doctor right away.
    hearing loss, sore throat,
    fever, dry mouth, thirst,
    side or stomach pain,
    nausea, vomiting, unusual
    bleeding or bruising,
    joint pain, jaundice,
    numbness or tingling in
    hands or feet.

    WARNINGS & PRECAUTIONS

    Don't take if:
    You are allergic to loop diuretics.

    Before you start, consult your doctor:

  • If you are allergic to any sulfa drug.
  • If you have liver or kidney disease.
  • If you have gout, diabetes or impaired hearing.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Infants & children: Use only under medical supervision. Prolonged use:
  • Impaired balance of water, salt and potassium in blood and body tissues.
  • Possible diabetes. Skin & sunlight: May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

    Driving or hazardous activities:
    No age-related problems expected.
    Discontinuing:
    Don't discontinue without doctor's advice until you complete
    prescribed dose, even though symptoms diminish or disappear.
    Others:
    Frequent laboratory studies to monitor potassium level in blood
    recommended. Eat foods rich in potassium or take potassium
    supplements. Consult doctor.

    POSSIBLE INTERACTION WITH OTHER DRUGS

    ACE inhibitors: Possible excessive
    captopril, enalapril, potassium in blood.
    lisinopril (see
    Drugs Glossary)
    Allopurinol Decreased allopurinol effect.
    Amiodarone Increased risk of heartbeat
    irregularity due to low potassium.
    Anticoagulants Abnormal clotting.
    (see Drugs Glossary)
    Antidepressants, Excessive blood-
    tricyclic (TCA, pressure drop.
    see Drugs Glossary)
    Antidiabetics (oral, Decreased
    see Drugs Glossary) antidiabetic effect.
    Antihypertensives Increased antihypertensive
    (see Drugs Glossary) effect. Dosages may require
    adjustment.
    Barbiturates Low blood pressure.
    (see Drugs Glossary)
    Beta-adrenergic Increased antihypertensive
    blockers (see effect. Dosages
    Drugs Glossary) may require adjustment.
    Calcium supplements Decreased calcium in
    (see Drugs Glossary) blood.
    Corticosteroids Decreased potassium.
    Cortisone drugs Excessive potassium loss.
    Digitalis Excessive potassium
    preparations loss could lead to
    (see Drugs Glossary) serious heart rhythm disorders.
    Digoxin Increased possibility of digitalis
    toxicity.
    Diuretics (other, Increased diuretic
    see Drugs Glossary) effect.
    Insulin Decreased insulin effect.
    Lithium Increased lithium toxicity.
    Narcotics Dangerous low blood pressure.
    Avoid.
    Nitrates Excessive blood-pressure drop.
    Non-steroidal Decreased
    anti-inflammatory loop diuretic effect.
    drugs (NSAIDs,
    see Drugs Glossary)
    Phenytoin Decreased loop diuretic effect.
    Potassium supplements Decreased potassium
    (see Drugs Glossary) effect.
    Probenecid Decreased probenecid effect.
    Salicylates Dangerous salicylate
    (including aspirin) retention.
    Sedatives Increased loop diuretic
    (see Drugs Glossary) effect.

    POSSIBLE INTERACTION WITH OTHER SUBSTANCES

    Tobacco: Decreased loop diuretic effect.

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