DISOPYRAMIDE |
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DISOPYRAMIDE
BRAND & GENERIC NAMES
Norpace
Norpace CR
Rythmodan
Rythmodan-LA
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Antiarrhythmic
USES
Corrects heart rhythm disorders.
DOSAGE & USAGE INFORMATION
How to take:
Extended-release tablet or capsule -- Swallow with liquid. If you
can't swallow whole, open capsule and take with liquid or food.
When to take:
At the same times each day.
If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2
hours, wait for next scheduled dose (don't double this dose).
What drug does:
Delays nerve impulses to heart to regulate heartbeat.
Time lapse before drug works:
Begins in 30 to 60 minutes. Must use for 5 to 7 days to
determine effectiveness.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Blood-pressure drop, irregular heartbeat, apnea, loss of
consciousness.
WHAT TO DO:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
If the child is unconscious and not breathing, give mouth-to-
mouth breathing. If there is no heartbeat, use cardiac massage
and mouth-to-mouth breathing (CPR). Don't try to make the child
vomit. If you can't get help quickly, take the child to nearest
emergency facility.
See EMERGENCY INFORMATION.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
Hives, rash, intense Seek emergency
itching, faintness treatment immediately.
soon after a dose
(anaphylaxis).
Common:
Hypoglycemia. Discontinue. Call doctor right
away.
Dry mouth, Continue. Call doctor
constipation, when convenient.
painful or difficult
urination, rapid
weight gain, blurred
vision.
Infrequent:
Dizziness, fainting, Discontinue. Call
confusion, doctor right away.
nervousness,
depression, chest
pain, slow or fast
heartbeat.
Swollen feet. Continue. Call doctor when
convenient.
Rare:
Shortness of breath, Discontinue. Seek
psychosis. emergency treatment.
Rash, sore throat, Discontinue. Call
fever, headache, doctor right away.
jaundice, muscle weakness.
Eye pain,
diminished Continue. Call doctor
sex drive, swollen when convenient.
breasts in men,
numbness or tingling
of hands and feet,
bleeding tendency.
WARNINGS & PRECAUTIONS
Don't take if:
You are allergic to disopyramide or any antiarrhythmic.
You have second-or third-degree heart block.
You have heart failure.
Before you start, consult your doctor:
If you react unfavorably to other antiarrhythmic drugs.
If you have had heart disease.
If you have low blood pressure.
If you have liver disease.
If you have glaucoma.
If you have enlarged prostate.
If you have myasthenia gravis.
If you take digitalis preparations or diuretics.
Pregnancy:
No proven harm to unborn child. Avoid if possible.
Infants & children:
Don't give to infants or young children unless prescribed and
monitored by your physician.
Prolonged use:
No age-related problems expected.
Skin & sunlight:
No age-related problems expected.
Driving or hazardous activities:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't climb
ladders or work in high places. Danger increases if you
drink alcohol or take medicine affecting alertness and reflexes,
such as antihistamines, tranquilizers, sedatives, pain medicine,
narcotics, or mind-altering drugs.
Discontinuing:
Don't discontinue without doctor's advice until you complete
prescribed dose, even though symptoms diminish or disappear.
Others:
If new illness, injury or surgery occurs, tell doctors of
disopyramide use.
POSSIBLE INTERACTION WITH OTHER DRUGS
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| Antiarrhythmics |
May increase effect |
| (see Drugs Glossary) |
and toxicity of each drug. |
| Anticholinergics |
Increased |
| (see Drugs Glossary) |
anticholinergic effect. |
| Anticoagulants (oral, |
Possible increased |
| see Drugs Glossary) |
anticoagulant effect. |
| Antihypertensives |
Increased |
| (see Drugs Glossary) |
antihypertensive effect. |
| Encainide |
Increased effect of toxicity on the |
| |
heart muscle. |
| Flecainide |
Possible irregular heartbeat. |
| Phenobarbital |
Increased metabolism, decreased |
| |
disopyramide effect. |
| Phenytoin |
Increased metabolism, decreased |
| |
disopyramide effect. |
| Rifampin |
Increased metabolism, |
| |
decreased disopyramide effect. |
| Tocainide |
Increased likelihood of adverse |
| |
reactions with either drug. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
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| Tobacco: |
May decrease disopyramide effect. |
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