| 
               
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    | CLONIDINE |   
    |  |  
    | CLONIDINE 
 
 
 
BRAND & GENERIC NAMES
 
Catapres Catapres-TTS
 Combipres
 Dixarit
 
 
 
 
BASIC INFORMATION
 
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Antihypertensive 
 
 
USES
 
Treatment of high blood pressure.
Prevention of vascular headaches.
Treatment of dysmenorrhea and menopausal "hot flashes."
Treatment of narcotic withdrawal syndrome.
Treatment of congestive heart failure. 
 
 
DOSAGE & USAGE INFORMATION
 
How to take:Tablet--Swallow with liquid.
Patches that attach to skin--Apply to clean, dry, hairless skin 
on arm or trunk.
When to take:
Daily dose at bedtime.
If you forget a dose: 
 Bedtime dose  -- If you forget your once-a-day dose, take it as
 soon as you remember. Don't double dose.
 What drug does:
 Relaxes and allows expansion of blood vessel walls.
 
 
 
Time lapse before drug works: Dial 0 (operator) or 911 (emergency) for an ambulance or 
medical help. Then give first aid immediately.
If the child is unconscious and not breathing, give mouth-to-
mouth breathing. If there is no heartbeat, use cardiac massage
and mouth-to-mouth breathing (CPR). Don't try to make the child 
vomit. If you can't get help quickly, take the child to nearest 
emergency facility.
See EMERGENCY INFORMATION.1 to 3 hours.
 Don't take with:
 Any other medicines, even over-the-counter drugs such as cough
 and cold medicines, nose drops, diet pills, laxatives or
 caffeine, without consulting your doctor.
 OVERDOSE
 SYMPTOMS:
 Vomiting, fainting, slow heartbeat, coma, diminished reflexes.
 WHAT TO DO:
 
 
 
 
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
 
 
SYMPTOMS                     WHAT TO DO
 
Life-threatening:Dizziness,                  Continue. Call doctor
drowsiness, weight           when convenient.
gain, lightheadedness 
upon rising from sitting 
or lying, swollen breasts.
Dry mouth.                  Continue. Tell doctor at next 
visit.
Infrequent:
Abnormal heart              Discontinue. Call
rhythm.                      doctor right away.
Headache; painful           Continue. Call doctor
glands in neck;              when convenient.
nightmares; nausea;
vomiting; cold fingers 
and toes; dry, burning 
eyes.
Insomnia,                   Continue. Tell doctor
constipation,                at next visit.
appetite loss,
diminished sex drive.
Rare:
Rash, itch.                 Discontinue. Call doctor right 
                             away.
Depression.                 Continue. Call doctor when 
                             convenient.None expected.
 Common:
 
 
 
 
WARNINGS & PRECAUTIONS
 
Don't take if:You are allergic to any alpha-adrenergic blocker.
You are under age 12.
 
 
Before you start, consult your doctor:If you will have surgery within 2 months, including dental 
surgery, requiring general or spinal anesthesia.
If you have heart disease or chronic kidney disease.
If you have a peripheral circulation disorder (intermittent 
claudication, Buerger's disease).
If you have history of depression.
Pregnancy:
 Studies inconclusive on harm to unborn child. Animal studies 
show fetal abnormalities. Decide with your doctor whether drug 
benefits justify risk to unborn child.
Infants & children:
 Use only under careful medical supervision after age 12. Avoid 
before age 12.
Prolonged use:
Don't discontinue without consulting doctor. Dose may require 
gradual reduction if you have taken drug for a long time. Doses 
of other drugs may also require adjustment.
Continued use may cause fluid retention, requiring addition of 
diuretic to treatment program.
Request yearly eye examinations.
Skin & sunlight:
 No age-related problems expected.
 
 
Driving or hazardous activities:Don't drive or pilot aircraft until you learn how medicine
 affects you. Don't work around dangerous machinery. Don't climb
 ladders or work in high places. Danger increases if you drink
 alcohol or take medicine affecting alertness and reflexes.
 Discontinuing:
 Don't discontinue abruptly. May cause rebound high blood
 pressure, anxiety, chest pain, insomnia, headache, nausea,
 irregular heartbeat, flushed face, sweating.
 Others:
 No age-related problems expected.
 
 
 
 
POSSIBLE INTERACTION WITH OTHER DRUGS
 
 
|  |  |  
| ACE inhibitors: | Possible excessive |  
| captopril, enalapril, | potassium in blood. |  
| lisinopril (see Drugs |  
| Glossary) |  
| Antidepressants, | Decreased clonidine |  
| tricyclic (TCA, | effect. |  
| Drugs See Glossary) |  
| Antihypertensives | Excessive blood- |  
| (other, see Drugs | pressure drop. |  
| Glossary) |  
| Appetite | Decreased clonidine |  
| suppressants | effect. |  
| (see Drugs Glossary) |  
| Beta-adrenergic | Possible precipitous |  
| blockers (see | change in blood |  
| Drugs Glossary) | pressure. |  
| Diuretics | Excessive blood- |  
| (see Drugs Glossary) | pressure drop. |  
| Ethinamate | Dangerous increased effects of |  
|  | ethinamate. Avoid combining. |  
| Fenfluramine | Possible increased clonidine |  
|  | effect. |  
| Fluoxetine | Increased depressant effects of |  
|  | both drugs. |  
| Guanfacine | Blood-pressure control impaired. |  
| Leucovorin | High alcohol content of leucovorin |  
|  | may cause adverse effects. |  
| Methyprylon | Increased sedative effect, perhaps |  
|  | to dangerous level. Avoid. |  
| Nitrates | Possible excessive blood-pressure |  
|  | drop. |  
 
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
 
 
| Marijuana: | Weakness on standing. |  
| Tobacco: | None expected. |  
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