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BETA-ADRENERGIC BLOCKING AGENTS

BETA-ADRENERGIC BLOCKING AGENTS

BRAND & GENERIC NAMES

ACEBUTOLOL NADOLOL

Apo-Metoprolol Normodyne
Apo-Propranolol Novometoprol
ATENOLOL Novopranol
Betaloc OXPRENOLOL
Betaloc Durules Panolol
Blocadren PINDOLOL
Corgard pms-Propranolol
Detensol PROPRANOLOL
ESMOLOL Sectral
Inderal Slow-Trasicor
Inderal LA Sotacor
Inderide SOTALOL
LABETALOL Tenormin
Lopresor TIMOLOL
Lopresor SR Trandate
Lopressor Trasicor
METOPROLOL Visken
Monitan

BASIC INFORMATION

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Beta-adrenergic blocker

    USES

  • Reduces angina attacks.
  • Stabilizes irregular heartbeat.
  • Lowers blood pressure.
  • Reduces frequency of migraine headaches. (Does not relieve headache pain.)
  • Other uses prescribed by your doctor.

    DOSAGE & USAGE INFORMATION

    How to take:
    Tablet, liquid or extended-release capsule -- Swallow with liquid.
    If you can't swallow whole, crumble tablet or open capsule and
    take with liquid or food. Don't crush capsule.
    When to take:
    With meals or immediately after.
    If you forget a dose:
    Take as soon as you remember. Return to regular schedule, but
    allow 3 hours between doses.
    What drug does:

  • Blocks certain actions of sympathetic nervous system.
  • Lowers heart's oxygen requirements.
  • Slows nerve impulses through heart.
  • Reduces blood vessel contraction in heart, scalp and other body parts.

    Time lapse before drug works:
    1 to 4 hours.
    Don't take with:
    Any other medicines, even over-the-counter drugs such as cough
    and cold medicines, nose drops, diet pills, laxatives or
    caffeine, without consulting your doctor.
    OVERDOSE
    SYMPTOMS:
    Weakness, slow or weak pulse, blood-pressure drop, fainting,
    difficulty breathing, convulsions, cold and sweaty skin.
    WHAT TO DO:

  • Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY INFORMATION.

    POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS

    SYMPTOMS WHAT TO DO

    Life-threatening:
    Congestive heart Discontinue. Seek
    failure. emergency treatment.
    Common:

  • Pulse slower than Discontinue. Call 50 beats per minute. doctor right away.
  • Drowsiness, fatigue, Continue. Call doctor numbness or tingling when convenient. of fingers or toes, dizziness, diarrhea, nausea, weakness.
  • Cold hands or feet; Continue. Tell doctor dry mouth, eyes and at next visit. skin. Infrequent:
  • Hallucinations, Discontinue. Call nightmares, insomnia, doctor right away. headache, difficult breathing, joint pain, anxiety.
  • Confusion, reduced Continue. Call doctor alertness, depression, when convenient. impotence.
  • Constipation. Continue. Tell doctor at next visit. Rare:
  • Rash, sore throat, Discontinue. Call fever. doctor right away.
  • Unusual bleeding and Continue. Call doctor bruising; dry, burning when convenient. eyes; impotence.

    WARNINGS & PRECAUTIONS

    Don't take if:

  • You are allergic to any beta-adrenergic blocker.
  • You have asthma.
  • You have hay fever symptoms.
  • You have taken MAO inhibitors in past 2 weeks.

    Before you start, consult your doctor:

  • If you have heart disease or poor circulation to the extremities.
  • If you have hay fever, asthma, chronic bronchitis, emphysema.
  • If you have overactive thyroid function.
  • If you have impaired liver or kidney function.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.
  • If you have diabetes or hypoglycemia. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Infants & children: Don't give to infants or young children unless prescribed and monitored by your physician. Prolonged use: Weakens heart muscle contractions. Skin & sunlight: No age-related problems expected.

    Driving or hazardous activities:
    Don't drive or pilot aircraft until you learn how medicine
    affects you. Don't work around dangerous machinery. Don't climb
    ladders or work in high places. Danger increases if you drink
    alcohol or take medicine affecting alertness and reflexes.
    Discontinuing:
    Don't discontinue without consulting doctor. Dose may require
    gradual reduction if you have taken drug for a long time. Doses
    of other drugs may also require adjustment.
    Others:
    May mask hypoglycemia.

    POSSIBLE INTERACTION WITH OTHER DRUGS

    ACE inhibitors: Increased antihypertensive
    captopril, enalapril, effects of both
    lisinopril (see drugs. Dosages may
    Drugs Glossary) require adjustment.
    Antidiabetics Increased antidiabetic
    (see Drugs Glossary) effect.
    Antihistamines Decreased
    (see Drugs Glossary) antihistamine effect.
    Antihypertensives Increased antihypertensive
    (see Drugs Glossary) effect.
    Barbiturates Increased barbiturate
    (see Drugs Glossary) effect. Dangerous sedation.
    Beta-agonists Decreased beta-agonist
    (see Drugs Glossary) effect.
    Betaxolol eyedrops Possible increased beta-adrenergic
    blocker effect.
    Digitalis Can either
    preparations increase or decrease
    (see Drugs Glossary) heart rate. Improves irregular
    heartbeat.
    Encainide Increased effect of toxicity on
    heart muscle.
    Indomethacin Decreased effect of beta-adrenergic
    blockers.
    Insulin Hypoglycemic effects may be
    prolonged.
    Levobunolol Possible increased
    eyedrops beta-adrenergic blocker effect.
    Molindone Increased tranquilizer effect.
    Narcotics Increased narcotic
    (see Drugs Glossary) effect. Dangerous sedation.
    Nitrates Possible excessive
    (see Drugs Glossary) blood-pressure drop.
    Non-steroidal Decreased antihypertensive
    anti-inflammatory effect of
    drugs (NSAIDs, beta-adrenergic blockers.
    see Drugs Glossary)
    Phenytoin Decreased beta-adrenergic blocker
    effect.
    Quinidine Slows heart excessively.
    Reserpine Increased reserpine effect.
    Excessive sedation and depression.
    Rifampin Decreased beta-adrenergic blocker
    effect.
    Timolol eyedrops Possible increased beta-adrenergic
    blocker effect.
    Tocainide May worsen congestive heart
    failure.
    Verapamil Increased effects of both drugs.

    POSSIBLE INTERACTION WITH OTHER SUBSTANCES

    Tobacco: Possible irregular heartbeat.

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