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AMILORIDE & HYDROCHLOROTHIAZIDE

AMILORIDE & HYDROCHLOROTHIAZIDE

BRAND AND GENERIC NAMES

Moduret
Moduretic

BASIC INFORMATION

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Diuretic (thiazide), antihypertensive

    USES

  • Controls, but doesn't cure, high blood pressure.
  • Reduces fluid retention (edema), decreasing likelihood of congestive heart failure.

    DOSAGE & USAGE INFORMATION

    How to take:
    Tablet -- Swallow with liquid. If you can't swallow whole, crumble
    tablet and take with liquid or food.
    When to take:
    At the same time each day, no later than 6 p.m.
    If you forget a dose:
    Take as soon as you remember up to 2 hours late. If more than 2
    hours, wait for next scheduled dose (don't double this dose).
    What drug does:

  • Forces sodium and water excretion, conserves potassium, reducing body fluid.
  • Relaxes muscle cells of small arteries.
  • Reduced body fluid and relaxed arteries lower blood pressure.

    Time lapse before drug works:
    2-6 hours. May require several weeks to lower blood pressure.
    Don't take with:
    Any other medicines, even over-the-counter drugs such as cough
    and cold medicines, nose drops, diet pills, laxatives or
    caffeine, without consulting your doctor.
    OVERDOSE
    SYMPTOMS:
    Cramps, weakness, drowsiness, weak pulse, coma, rapid, irregular
    heartbeat.
    WHAT TO DO:

  • Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY INFORMATION.

    POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS

    SYMPTOMS WHAT TO DO

    Life-threatening:
    None expected.
    Common:

  • Increased thirst, Discontinue. Call irregular heartbeat, doctor right away. cramps in muscles, numbness and tingling in hands and feet, thready pulse, shortness of breath.
  • Tiredness, weakness, Continue. Call doctor dry mouth, diarrhea, when convenient. headache, appetite loss, nausea. Infrequent: Mood changes, Continue. Call doctor constipation, decreased when convenient. sex function, dizziness, lightheadedness. Rare: Jaundice; unusual Discontinue. Seek bleeding or bruising; emergency treatment. abdominal pain with nausea and vomiting; sore throat, fever, sores in mouth; hives, skin rash; joint pain.

    WARNINGS & PRECAUTIONS

    Don't take if:
    You are allergic to amiloride or any thiazide diuretic drug.

    Before you start, consult your doctor:

  • If you are allergic to any sulfa drug.
  • If you have gout, diabetes, heart disease.
  • If you have liver, pancreas or kidney disorder. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Infants & children: Don't give to infants or young children unless prescribed and monitored by your physician. Prolonged use: You may need medicine to treat high blood pressure for the rest of your life. Skin & sunlight: May cause rash or intensify sunburn in areas exposed to sun or sunlamp. Avoid overexposure.

    Driving or hazardous activities:
    Don't drive or pilot aircraft until you learn how medicine
    affects you. Don't work around dangerous machinery. Don't climb
    ladders or work in high places. Danger increases if you
    drink alcohol or take medicine affecting alertness and reflexes,
    such as as antihistamines, tranquilizers, sedatives, pain
    medicine, narcotics and mind-altering drugs.
    Discontinuing:
    Don't discontinue without medical advice.
    Others:

  • Hot weather and fever may cause dehydration and drop in blood pressure. Dose may require temporary adjustment. Weigh daily and report any unexpected weight decreases to your doctor.
  • May cause rise in uric acid, leading to gout.
  • May cause blood-sugar rise in diabetics.
  • Get periodic check-ups and potassium-level laboratory tests.

    POSSIBLE INTERACTION WITH OTHER DRUGS

    Allopurinol Decreased allopurinol effect.
    Antidepressants, Dangerous drop in
    tricyclic (TCA, blood pressure. Avoid
    see Drugs Glossary) combination unless under medical
    supervision.
    Antihypertensives Increased effect of
    (other, see Drugs both drugs.
    Glossary)
    Barbiturates Increased
    (see Drugs Glossary) hydrochlorothiazide effect.
    Beta-adrenergic Increased antihypertensive effect.
    blockers (see Drugs Dosages of both drugs may require
    Glossary) adjustments.
    Blood-bank blood Increased potassium levels.
    Cortisone drugs Excessive potassium
    (see Drugs Glossary) loss that causes dangerous heart
    rhythms.
    Digitalis Excessive potassium
    preparations loss that causes dangerous heart
    (see Drugs Glossary) rhythms.
    Diuretics (thiazide, Increased diuretic effect.
    see Drugs Glossary)
    Diuretics (other, Increased effect of
    see Drugs Glossary) both drugs.
    Indapamide Increased diuretic effect.
    Lithium Possible lithium toxicity.
    MAO inhibitors Increased
    (see Drugs Glossary) hydrochlorothiazide effect.
    Nitrates Excessive
    (see Drugs Glossary) blood-pressure drop.
    Oxprenolol Increased antihypertensive effect.
    Dosages may require adjustment.
    Probenecid Decreased probenecid effect.
    Sodium bicarbonate Decreased potassium levels.

    POSSIBLE INTERACTION WITH OTHER SUBSTANCES

    Marijuana: May increase blood pressure.
    Tobacco: None expected.

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