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Brand & Generic Names

Amaphen Florinal
Anacin Histosal
Anoquan Kolephrin
A.P.C. Korigesic
Aspirin Compound w/Codeine Lanorinal
Aspirin Free Bayer Select Nodoz
Maximum Strength Headache Pacaps
Pain Relief Caplets P-A-C Compound
Aspirin-Free Excedrin Propoxyphene Compound
Caplets Quick Pep
Cafermine S-A-C
Cafetrate Salatin
Caffedrine Saleto-D
Caffefrine Caplets Salocol
Citrated Caffeine Scot-tussin Original
Dexitac 5-Action Cold Medicine
Dristan Sinaplis
Dristan AF Supac
Dristan AF Plus Synalgos-DC
Esgic Tirend
Excedrin Caplets Triaminicin with Codeine
Excedrin Extra Strength Trigesic
Caplets Two-Dyne
Excedrin Extra Strength Vanquish
Tablets Vivarin
Fendol Wigraine

Basic Information

  • Habit forming? Yes
  • Prescription needed? No
  • Available as generic? Yes
  • Drug class: Stimulant (xanthine), vasoconstrictor


  • Treatment for drowsiness and fatigue.
  • Treatment for migraine and other vascular headaches in combination with ergot.

Dosage & Usage Information

How to take:
Tablet or liquid--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food.
Extended-release capsules--Swallow whole with liquid.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Constricts blood vessel walls.
Stimulates central nervous system.

Time lapse before drug works:
30 minutes.

Don't take with:
Non-prescription drugs without consulting doctor.
Any other medicine without consulting your doctor or pharmacist.


Excitement, insomnia, rapid heartbeat (infants can have slow heartbeat), confusion, fever, hallucinations, convulsions, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Rapid heartbeat, low blood sugar (hunger, anxiety, cold sweats, rapid pulse) with tremor, irritability (mild).
  • Nervousness, insomnia.
  • Increased urination.


  • Confusion, irritability (severe).
  • Nausea, indigestion, burning feeling in stomach.


    None expected.

Warnings & Precautions

Don't take if:

  • You are allergic to any stimulant.
  • You have heart disease.
  • You have active peptic ulcer of stomach or duodenum.

Before you start, consult your doctor:

  • If you have irregular heartbeat.
  • If you have hypoglycemia (low blood sugar).
  • If you have epilepsy.
  • If you have high blood pressure.
  • If you have insomnia.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:
Stomach ulcers.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

Will cause withdrawal symptoms of headache, irritability, drowsiness. Discontinue gradually if you use caffeine for a month or more.

May produce or aggravate fibrocystic disease of the breast in women.

Possible Interaction with Other Drugs

------------------------ -----------------------
Caffeine-containing Increased risk of overstimulation.
Central nervous Increased risk of overstimulation.
Cimetidine Increased caffeine effect.
Contraceptives*, Increased caffeine
oral effect.
Isoniazid Increased caffeine effect.
MAO inhibitors* Dangerous blood pressure rise.
Sedatives* Decreased sedative effect.
Sleep inducers* Decreased sedative effect.
Sympathomimetics* Overstimulation.
Thyroid hormones* Increased thyroid effect.
Tranquilizers* Decreased tranquilizer effect.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Decreased alcohol effect.
Caffeine drinks (coffee, Increased caffeine effect.
Cocaine Convulsions or excessive
Foods: No proven problems.
Marijuana: Increased effect of both drugs. May
lead to dangerous, rapid heartbeat.
Tobacco: Increased heartbeat. Avoid.
Decreased caffeine effect.

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