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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? U.S.: No Canada: Yes
  • Available as generic? No
  • Drug class: Antihistamine, antiemetic, anti-motion sickness


    Prevents motion sickness.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and chew or take with liquid or food.

When to take:
30 minutes to 1 hour before traveling.

If you forget a dose:
Take as soon as you remember. Wait 4 hours for next dose.

What drug does:
Reduces sensitivity of nerve endings in inner ear, blocking messages to brain's vomiting center.

Time lapse before drug works:
30 to 60 minutes.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Drowsiness, confusion, incoordination, stupor, coma, weak pulse, shallow breathing, hallucinations.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.




  • Headache, diarrhea or constipation, fast heartbeat.
  • Dry mouth, nose, throat.


  • Rash or hives.
  • Restlessness, excitement, insomnia, blurred vision, frequent urination, difficult urination, hallucinations.
  • Appetite loss, nausea.

Warnings & Precautions

Don't take if:

  • You are allergic to meclizine, buclizine or cyclizine.
  • You have taken MAO inhibitors in the past 2 weeks.

Before you start, consult your doctor:

  • If you have glaucoma.
  • If you have prostate enlargement.
  • If you have reacted badly to any antihistamine.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons, especially impaired urination from enlarged prostate gland.

Studies inconclusive on harm to unborn child. Animal studies show fetal abnormalities. Decide with your doctor whether drug benefits justify risk to unborn child.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Safety not established. Avoid if less than 12 years old.

Prolonged use:
No problems expected.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Don't fly aircraft. Don't drive until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

No problems expected.

Buclizine contains tartrazine dye. Avoid if allergic (especially aspirin hypersensitivity).

Possible Interaction with Other Drugs

------------------------ -----------------------
Amphetamines* May decrease drowsiness caused by
Anticholinergics* Increased effect of both drugs.
Antidepressants, Increased effect of
tricyclic (TCA)* both drugs.
Carteolol Decreased antihistamine effect.
Cisapride Decreased buclizine effect.
Clozapine Toxic effect on the central nervous
Dronabinol Increases effect of buclizine.
Ethinamate Dangerous increased effects of
ethinamate. Avoid combining.
Fluoxetine Increased depressant effects of
both drugs.
Guanfacine May increase depressant effects of
either drug.
MAO inhibitors* Increased buclizine effect.
Methyprylon Increased sedative effect, perhaps
to dangerous level. Avoid.
Nabilone Greater depression of central
nervous system.
Narcotics* Increased effect of both drugs.
Pain relievers* Increased effect of both drugs.
Sedatives* Increased effect of both drugs.
Sertraline Increased depressive effects of
both drugs.
Sleep inducers* Increased effect of both drugs.
Sotalol Increased antihistamine effect.
Tranquilizers* Increased effect of both drugs.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Increased sedation. Avoid.
Caffeine drinks. May decrease drowsiness.
Cocaine: None expected.
Foods: None expected.
Marijuana: Increased drowsiness, dry mouth.
Tobacco: None expected.

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