ATROPINE, HYOSCYAMINE, METHENAMINE, METHYLENE BLUE,

Brand & Generic Names

Atrosept	Urimed
Dolsed	Urinary Antiseptic No. 2
Hexalol	Urised
Prosed/DS	Uriseptic
Trac Tabs 2X	Uritab
U-Tract	Uritin
UAA	Uro-Ves
Uridon Modified

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? No
• Drug class: Analgesic (urinary), antispasmodic, anti-infective (urinary)

Uses

A combination medicine to control infection, spasms and pain caused by urinary tract infections.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation.

When to take:
30 minutes before meals (unless directed otherwise by doctor).

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Makes urine acid. Blocks nerve impulses at parasympathetic nerve endings, preventing muscle contractions and gland secretions of organs involved. Methenamine destroys some germs.

Time lapse before drug works:
15 to 30 minutes.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
Dilated pupils, rapid pulse and breathing, dizziness, fever, hallucinations, confusion, slurred speech, agitation, flushed face, convulsions, coma.

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

Heartbeat irregularity, Seek emergency shortness of breath or treatment immediately. difficulty breathing.

Common:

Dry mouth, throat, ears, nose.

Infrequent:

• Flushed, red face; drowsiness; difficult urination; nausea and vomiting; abdominal pain; ringing or buzzing in ears; severe drowsiness; back pain; lightheadedness.
• Headache, nasal congestion, altered taste.

Rare:

Blurred vision; pain in eyes; skin rash, hives.

Warnings & Precautions

Don't take if:

• You are allergic to any of the ingredients or aspirin.
• Brain damage in child.
• You have glaucoma.

Before you start, consult your doctor:

• If you are on any special diet such as low-sodium.
• If you have had a hiatal hernia, bronchitis, asthma, liver disease, stomach or duodenal ulcers.
• If you have asthma, nasal polyps, bleeding disorder or enlarged prostate.
• If you will have any surgery within 2 months.
• If you have heart disease.

Over age 60:

• Adverse reactions and side effects may be more frequent and severe than in younger persons.
• More likely to cause hidden bleeding in stomach or intestines. Watch for dark stools.

Pregnancy:
Risk to unborn child outweighs benefits. Don't use.

Breast-feeding:
Drug passes into milk. Avoid or discontinue nursing until you finish medicine.

Infants & children:
Side effects more likely. Not recommended in children under 12.

Prolonged use:
May lead to constipation or kidney damage. Request lab studies to monitor effects of prolonged use.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
May disqualify for piloting aircraft during time you take medicine.

Discontinuing:
May be unnecessary to finish medicine. Follow your symptoms and doctor's advice.

Others:

• Salicylates can complicate surgery, pregnancy, labor and delivery, and illness.
• Urine tests for blood sugar may be inaccurate.
• Drink cranberry juice or eat prunes or plums to help make urine more acid.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Allopurinol	Decreased allopurinol effect.
Amantadine	Increased atropine and belladonna
	effect.
Antacids*	Decreased salicylate and
	methenamine effect.
Anticoagulants*	Increased anticoagulant effect.
	Abnormal bleeding.
Anticholinergics,	Increased atropine and
other*	belladonna effect.
Antidepressants,	Increased
other*	sedation.
Antidiabetics, oral*	Low blood sugar.
Antihistamines*	Increased atropine and hyoscyamine
	effect.
Aspirin	Likely salicylate toxicity.
Beta-adrenergic	Decreased antihypertensive
blockers*	effect.
Carbonic anhydrase	Decreased
inhibitors*	methenamine effect.
Cortisone drugs*	Increased internal-eye pressure,
	increased cortisone effect. Risk of
	ulcers and stomach bleeding.
Diuretics, thiazide*	Decreased urine acidity.
Furosemide	Possible salicylate toxicity.
Gold compounds*	Increased likelihood of kidney
	damage.
Haloperidol	Increased internal-eye pressure.
Indomethacin	Risk of stomach bleeding and
	ulcers.
Ketoconazole	Reduced ketoconazole effect.
MAO inhibitors*	Increased belladonna and atropine
	effect.
Meperidine	Increased atropine and hyoscyamine
	effect.
Methylphenidate	Increased atropine and hyoscyamine
	effect.
Minoxidil	Decreased minoxidil effect.
Non-steroidal	Risk of stomach
anti-inflammatory	bleeding and ulcers.
Orphenadrine	Increased atropine and hyoscyamine
	effect.
Oxprenolol	Decreased antihypertensive effect
	of oxprenolol.
Para-aminosalicylic	Possible salicylate
acid (PAS)	toxicity.
Penicillins*	Increased effect of both drugs.
Phenobarbital	Decreased salicylate effect.
Phenothiazines*	Increased atropine and hyoscyamine
	effect.
Phenytoin	Increased phenytoin effect.
Pilocarpine	Loss of pilocarpine effect in
	glaucoma treatment.
Potassium	Possible intestinal
supplements*	ulcers with oral potassium tablets.
Probenecid	Decreased probenecid effect.
Propranolol	Decreased salicylate effect.
Rauwolfia alkaloids*	Decreased salicylate effect.
Salicylates, other*	Likely salicylate toxicity.
Sedatives* or central	Increased sedative effect of
nervous system (CNS)	both drugs.
Sodium bicarbonate	Decreased methenamine effect.
Spironolactone	Decreased spironolactone effect.
Sulfa drugs*	Possible kidney damage.
Sulfinpyrazone	Decreased sulfinpyrazone effect.
Terfenadine	May conceal symptoms of salicylate
	overdose, such as ringing in ears.
Vitamin C (1 to 4	Increased effect of
grams per day)	methenamine, contributing to urine
	acidity; decreased atropine effect;
	possible salicylate toxicity.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Excessive sedation. Possible
	stomach irritation and bleeding.
	Avoid.
Beverages:	None expected.
Cocaine:	Excessively rapid heartbeat. Avoid.
Foods:	None expected.
Marijuana:	Drowsiness and dry mouth. May slow
	body's recovery.
Tobacco:	Dry mouth.