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ATROPINE


Brand & Generic Names

ATROPINE


Basic Information

  • Habit forming? No
  • Prescription needed? Low strength: No High strength: Yes
  • Available as generic? Yes
  • Drug class: Antispasmodic, anticholinergic

Uses

  • Reduces spasms of digestive system, bladder and urethra.
  • Treatment of bronchial spasms.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation.
Aerosol--Dilute in saline and inhale as nebulizer.

When to take:
30 minutes before meals (unless directed otherwise by doctor).

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Blocks nerve impulses at parasympathetic nerve endings, preventing muscle contractions and gland secretions of organs involved.

Time lapse before drug works:
15 to 30 minutes.

Don't take with:
Antacids* or antidiarrheals*.
Any other medicine without consulting your doctor or pharmacist.


Overdose

SYMPTOMS:
Dilated pupils, rapid pulse and breathing, dizziness, fever, hallucinations, confusion, slurred speech, agitation, flushed face, convulsions, coma.

WHAT TO DO:

  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

    In case of overdose, see Overdose section.

Common:

  • Confusion, delirium, rapid heartbeat.
  • Nausea, vomiting, decreased sweating.
  • Constipation.
  • Dryness in ears, nose, throat, mouth.

Infrequent:

  • Headache, difficult or painful urination, nasal congestion, altered taste.
  • Lightheadedness.

Rare:

    Rash or hives, eye pain, blurred vision, fever.

Warnings & Precautions

Don't take if:

  • You are allergic to any anticholinergic.
  • You have trouble with stomach bloating.
  • You have difficulty emptying your bladder completely.
  • You have narrow-angle glaucoma.
  • You have severe ulcerative colitis.

Before you start, consult your doctor:

  • If you have open-angle glaucoma.
  • If you have angina.
  • If you have chronic bronchitis or asthma.
  • If you have liver, kidney or thyroid disease.
  • If you have hiatal hernia.
  • If you have enlarged prostate.
  • If you have myasthenia gravis.
  • If you have peptic ulcer.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Studies inconclusive on harm to unborn child. Animal studies show fetal abnormalities. Decide with your doctor whether drug benefits justify risk to unborn child.

Breast-feeding:
Drug passes into milk and decreases milk flow. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Use only under medical supervision.

Prolonged use:
Chronic constipation, possible fecal impaction. Consult doctor immediately.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Use disqualifies you for piloting aircraft. Otherwise, no problems expected.

Discontinuing:
May be unnecessary to finish medicine. Follow doctor's instructions.

Others:
Advise any doctor or dentist whom you consult that you take this medicine.


Possible Interaction with Other Drugs

GENERIC NAME COMBINED EFFECT
------------------------ -----------------------
Amantadine Increased atropine effect.
Anticholinergics, Increased atropine
other* effect.
Antidepressants, Increased atropine
tricyclic (TCA)* effect. Increased sedation.
Antihistamines* Increased atropine effect.
Attapulgite Decreased atropine effect.
Cortisone drugs* Increased internal-eye pressure.
Disopyramide Increased atropine effect.
Haloperidol Increased internal-eye pressure.
Ketoconazole Decreased ketoconazole effect.
MAO inhibitors* Increased atropine effect.
Meperidine Increased atropine effect.
Methylphenidate Increased atropine effect.
Molindone Increased anticholinergic effect.
Nitrates* Increased internal-eye pressure.
Nizatidine Increased nizatidine effect.
Orphenadrine Increased atropine effect.
Phenothiazines* Increased atropine effect.
Pilocarpine Loss of pilocarpine effect in
glaucoma treatment.
Potassium Possible intestinal
supplements* ulcers with oral potassium tablets.
Quinidine Increased atropine effect.
Sedatives* or central Increased
nervous system (CNS) sedative effect of both drugs.
Vitamin C Decreased atropine effect. Avoid
large doses of vitamin C.


Possible Interaction with Other Substances

INTERACTS WITH COMBINED EFFECT
--------------- ---------------
Alcohol: None expected.
Beverages: None expected.
Cocaine: Excessively rapid heartbeat. Avoid.
Foods: None expected.
Marijuana: Drowsiness and dry mouth.
Tobacco: None expected.



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