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Brand & Generic Names

Anergan 25 Pherazine VC
Anergan 50 Pherazine VC with Codeine
Histantil PMS Promethazine
Mallergan-VC with Codeine Pro-50
Panectyl Prometh VC Plain
Pentazine Prometh VC with Codeine
Phenameth Prometh-25
Phenameth VC with Codeine Prometh-50
Phenazine 25 Prometharazine VC
Phencen-50 Prorex-25
Phenergan Prorex-50
Phenergan Fortis Prothazine
Phenergan Plain Prothazine Plain
Phenergan VC Tacaryl
Phenergan VC with Codeine TRIMEPRAZINE
Phenergan with Codeine V-Gan-25
Phenergan with Dextromorphen V-Gan-50

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Tranquilizer (phenothiazine), antihistamine


  • Relieves itching of hives, skin allergies, chickenpox.
  • Treatment for hay fever, motion sickness, vertigo.

Dosage & Usage Information

How to take:
Tablet or syrup--Swallow with liquid or food to lessen stomach irritation.
Extended-release capsules--Swallow each dose whole. If you take regular tablets, you may chew or crush them.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Blocks histamine action in skin.

Time lapse before drug works:
1 to 2 hours.

Don't take with:
Antacid or medicine for diarrhea.
Non-prescription drug for cough, cold or allergy.
Any other medicine without consulting your doctor or pharmacist.


Fast heartbeat, flushed face, shortness of breath, clumsiness, drowsiness, muscle spasms, jerking movements of head and face.


  • Dial 911 (emergency) or 0 (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see previous section.


  • Restlessness, tremor, drowsiness, tiredness, weakness.
  • Decreased sweating, dry mouth, nasal congestion, constipa- tion.


  • Fainting.
  • Rash, muscle spasms of face and neck, unsteady gait.
  • Difficult urination, less interest in sex, swollen breasts, menstrual irregularities, dizziness, nausea, vomiting.


    Change in vision, sore throat, fever, jaundice, confusion, nightmares, unusual excitement.

Warnings & Precautions

Don't take if:

  • You are allergic to any phenothiazine.
  • You have a blood or bone marrow disease.

Before you start, consult your doctor:

  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.
  • If you have asthma, emphysema or other lung disorder.
  • If you take non-prescription ulcer medicine, asthma medicine or amphetamines.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons. More likely to develop tardive dyskinesia (involuntary movement of jaws, lips, tongue, chewing). Report this to your doctor immediately. Early treatment can help.

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Don't give to children younger than 2.

Prolonged use:

  • May lead to tardive dyskinesia (involuntary movement of jaws, lips, tongue; chewing).
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit), liver function, eyes.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp. Skin may remain sensitive for 3 months after discontinuing.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes.

May be unnecessary to finish medicine. Follow doctor's instructions.

May affect results in some medical tests.

Possible Interaction with Other Drugs

------------------------- -----------------------
Antacids* Decreased antihistamine effect.
Anticholinergics* Increased anticholinergic effect.
Anticonvulsants, Increased anticonvulsant effect.
Antidepressants, Increased antihistamine effect.
Antihistamines*, Increased antihistamine effect.
Antithyroid drugs* Increased risk of bone marrow
Appetite suppressants* Decreased appetite suppression effect.
Barbiturates* Oversedation.
Carteolol Decreased antihistamine effect.
Central nervous Dangerous degree of sedation.
Cisapride Decreased antihistamine effect.
Clozapine Toxic effect on the central nervous
Dronabinol Increased effects of both drugs.
Epinephrine Decreased epinephrine effect.
Ethinamate Dangerous increased effects of
ethinamate. Avoid combining.
Extrapyramidal Increased frequency and severity of
reaction-causing extrapyramidal reactions.
Fluoxetine Increased depressant effects of
both drugs.
Guanfacine May increase depressant effects of
either medicine.
Guanethidine Decreased guanethidine effect.
Leucovorin High alcohol content of leucovorin
may cause adverse effects.
Levodopa Decreased levodopa effect.
MAO inhibitors* Increased antihistamine effect.
Methyprylon May increase sedative effect to
dangerous level. Avoid.
Metyrosine Increased likelihood of toxic
symptoms of each.
Mind-altering Increased effect of mind-altering
drugs* drugs.
Molindone Increased sedative and antihistamine
Nabilone Greater depression of central
nervous system.
Narcotics* Increased narcotic effect.
Sedatives* Increased sedative effect.
Sertraline Increased depressive effects of both
Sotalol Increased antihistamine effect.
Tranquilizers* Increased tranquilizer effect. Avoid.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Dangerous oversedation.
Beverages: None expected.
Cocaine: Decreased trimeprazine effect. Avoid.
Foods: None expected.
Marijuana: Drowsiness.

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