XYLOMETAZOLINE

Brand & Generic Names

Chlorohist-LA	Otrivin Nasal Drops
Neo-Synephrine II Long-	Otrivin Nasal Spray
Acting Nasal Spray	Otrivin Pediatric Decon-
Adult Strength	gestant Nose Drops
Neo-Synephrine II Long-	Otrivin Pediatric Nasal
Acting Nose Drops	Drops
Adult Strength	Otrivin Pediatric Nasal
Otrivin Decongestant Nose	Spray
Drops	Otrivin With M-D Pump

Basic Information

• Habit forming? No
• Prescription needed? No
• Available as generic? Yes
• Drug class: Sympathomimetic

Uses

Relieves congestion of nose, sinuses and throat from allergies and infections.

Dosage & Usage Information

How to take:
Nasal solution, nasal spray--Use as directed on label. Avoid contamination. Don't use same container for more than 1 person.

When to take:
When needed, no more often than every 4 hours.

If you forget a dose:
Take as soon as you remember. Wait 4 hours for next dose.

What drug does:
Constricts walls of small arteries in nose, sinuses and eustachian tubes.

Time lapse before drug works:
5 to 30 minutes.

Don't take with:
Non-prescription drugs for allergy, cough or cold without consulting doctor.
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
Headache, sweating, anxiety, agitation, rapid and irregular heartbeat (rare occurrence with systemic absorption).

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). If you can't get help quickly, take patient to nearest emergency facility.
• See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

In case of overdose, see previous section.

Common:

None expected.

Infrequent:

Burning, dry or stinging nasal passages.

Rare:

Rebound congestion (increased runny or stuffy nose); headache, insomnia, nervousness (may occur with systemic absorption).

Warnings & Precautions

Don't take if:
You are allergic to any sympathomimetic nasal spray.

Before you start, consult your doctor:

• If you have heart disease or high blood pressure.
• If you have diabetes.
• If you have overactive thyroid.
• If you have taken MAO inhibitors in past 2 weeks.
• If you have glaucoma.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
No proven harm to unborn child. Avoid if possible. Consult doctor.

Breast-feeding:
No proven problems. Consult doctor.

Infants & children:
Don't give to children younger than 2.

Prolonged use:
Drug may lose effectiveness, cause increased congestion (rebound effect*) and irritate nasal membranes.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

Discontinuing:
May be unnecessary to finish medicine. Follow doctor's instructions.

Others:
No problems expected.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Antidepressants,	Possible rise in blood pressure.
Maprotiline	Possible increased blood
	pressure.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	None expected.
Caffeine drinks.	Nervousness or insomnia.
Cocaine:	High risk of heartbeat
	irregularities and high blood
	pressure.
Foods:	None expected.
Marijuana:	Overstimulation. Avoid.
Tobacco:	None expected.