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Brand & Generic Names

Apo-Sulfatrim Sulfamethoprim
Bactrim Sulfaprim
Bethaprim Sulfatrim
Cheragan with TMP Sulfoxaprim
Cotrim Sulmeprim
Novotrimel Triazole
Proloprim Trimeth-Sulfa
Protrin Trimpex
Roubac Trisulfam
Septra Uroplus

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Antimicrobial


  • Treats for urinary tract infections susceptible to trimethoprim.
  • Helps prevent recurrent urinary tract infections if taken once a day.
  • Treats pneumocystis carinii pneumonia.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation.

When to take:
Space doses evenly in 24 hours to keep constant amount in urine.

If you forget a dose:
Take as soon as possible. Wait 5 to 6 hours before next dose. Then return to regular schedule.

What drug does:
Stops harmful bacterial germs from multiplying. Will not kill viruses.

Time lapse before drug works:
2 to 5 days.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Nausea, vomiting, diarrhea.


    Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects


    None expected.


  • Rash, itchy skin.
  • Unusual taste.


  • Diarrhea, nausea, vomiting, abdominal pain.
  • Headache, appetite loss, sore mouth or tongue.


  • Blue fingernails, lips and skin; difficult breathing.
  • Sore throat, fever, anemia, jaundice, unusual bleeding or bruising.

Warnings & Precautions

Don't take if:

  • You are allergic to trimethoprim or any sulfa drug.
  • You are anemic due to folic acid deficiency.

Before you start, consult your doctor:
If you have had liver or kidney disease.

Over age 60:

  • Reduced liver and kidney function may require reduced dose.
  • More likely to have severe anal and genital itch.
  • Increased susceptibility to anemia.

Studies inconclusive on harm to unborn child. Animal studies show fetal abnormalities. Decide with your doctor whether drug benefits justify risk to unborn child.

No proven harm to unborn child. Avoid if possible. Consult doctor.

Infants & children:
Use under medical supervision only.

Prolonged use:

  • Anemia.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit).

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
No problems expected.

Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear.

No problems expected.

Possible Interaction with Other Drugs

------------------------ -----------------------
Bone marrow depressants* Increased possibility of bone
marrow supression.
Clozapine Toxic effect on bone marrow.
Folate antagonists*, Increased risk of anemia.
Tiopronin Increased risk of toxicity to bone

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Increased alcohol effect with
Bactrim or Septra.
Beverages: None expected.
Cocaine: No proven problems.
Foods: None expected.
Marijuana: None expected.
Tobacco: None expected.

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