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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Antihypertensive, diuretic


  • Reduces fluid retention (edema).
  • Reduces potassium loss.

Dosage & Usage Information

How to take:
Capsule--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, open capsule and take with liquid or food.

When to take:
1 dose per day--Take after breakfast.
More than 1 dose per day--Take last dose no later than 6 p.m.

If you forget a dose:
Take as soon as you remember up to 6 hours late. If more than 6 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Increases urine production to eliminate sodium and water from body while conserving potassium.

Time lapse before drug works:
2 hours. May require 2 to 3 days for maximum benefit.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Lethargy, nausea, vomiting, hypotension, irregular heartbeat, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    Hives, rash, intense Seek emergency itching, faintness treatment immediately. soon after a dose (anaphylaxis).


    Constipation, decreased interest in sex.


  • Drowsiness, thirst, dry mouth, confusion, irregular heartbeat, shortness of breath, kidney stones, unusual tiredness, weakness, fever and chills, cracked mouth corners, black stools, dry mouth.
  • Diarrhea.
  • Anxiety.


  • Rash, sore throat, red or inflamed tongue, unusual bleeding or bruising.
  • Headache.

Warnings & Precautions

Don't take if:

  • You are allergic to triamterene.
  • You have had severe liver or kidney disease.

Before you start, consult your doctor:

  • If you have gout, diabetes, kidney stones.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:

  • Warm weather or fever can decrease blood pressure. Dose may require adjustment.
  • Extended use can increase blood clots.

No proven harm to unborn child. Avoid if possible. Consult doctor.

Safety not established. Consult doctor.

Infants & children:
Used infrequently. Use only under medical supervision.

Prolonged use:

  • Potassium retention which may lead to heart rhythm problems.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check blood pressure, kidney function, ECG* and serum electrolytes.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Avoid if you feel drowsy or confused. Otherwise, no problems expected.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.

No problems expected.

Possible Interaction with Other Drugs

------------------------ -----------------------
ACE inhibitors*: Possible excessive potassium
captopril, enalapril, in blood.
Amiloride Dangerous retention of potassium.
Amiodarone Increased risk of heartbeat
irregularity due to low potassium.
Antihypertensives*, Increased effect of other
other antihypertensives.
Calcium supplements* Increased calcium in blood.
Carteolol Increased antihypertensive effect.
Cyclosporine Possible excessive potassium in
Digitalis Possible decreased digitalis
preparations* effect.
Indomethacin Possible acute renal failure.
Lithium Increased lithium effect.
Nicardipine Blood pressure drop. Dosages may
require adjustment.
Nimodipine Dangerous blood pressure drop.
Nitrates* Excessive blood pressure drop.
Non-steroidal Possible excessive potassium
anti-inflammatory in blood.
Potassium Possible excessive potassium
supplements* retention.
Potassium iodide May raise potassium level in blood
to toxic levels.
Sotalol Increased antihypertensive effect.
Spironolactone Dangerous retention of potassium.
Terazosin Decreases effectiveness of

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: None expected.
Low-salt milk. Possible potassium toxicity.
Cocaine: Increased risk of heart block and
high blood pressure.
Salt, substitutes. Possible potassium toxicity.
Marijuana: Daily use--Fainting likely.
Tobacco: None expected.

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