TICLOPIDINE

Brand & Generic Names

Ticlid

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? No
• Drug class: Platelet aggregation inhibitor

Uses

Decreases the risk of stroke in patients who have warning signs of stroke or who have had strokes caused by blood clots.

Dosage & Usage Information

How to take:
Tablets--Swallow with liquid. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
Twice a day with food as directed.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Inhibits the clumping of platelets and thereby prevents blood clotting.

Time lapse before drug works:
2 hours.

Don't take with:
Any other drugs (particularly aspirin) without consulting doctor or pharmacist.

Overdose

SYMPTOMS:
Bloody vomit or excessive bleeding from gums, nose or rectum.

WHAT TO DO:

Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.

Possible Adverse Reactions or Side Effects

Life-threatening:

None expected.

Common:

• Diarrhea, elevated level of cholesterol in blood.
• Nausea, skin rash, abdominal pain.

Infrequent:

• Unusual bleeding or bruising.
• Headache.

Rare:

• Sore throat, mouth ulcers, fever, chills.
• Dizziness, loss of appetite, gaseousness.

Warnings & Precautions

Don't take if:

• You are allergic to ticlopidine.
• You have reduced white blood cells (neutropenia).

Before you start, consult your doctor:

• If you have liver disease, kidney disease, peptic ulcers or diverticulitis.
• If you have any bleeding disorder.

Over age 60:
No special problems expected.

Pregnancy:
Use during pregnancy only if clearly needed. Consult doctor.

Breast-feeding:
Safety not established. Consult doctor.

Infants & children:
Not recommended. Safety has not been established.

Prolonged use:
No special problems expected.

Skin & sunlight:
No special problems expected.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how the medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places.

Discontinuing:
No special problems expected.

Others:

• Advise any doctor or dentist whom you consult that you take this medicine. This is particularly important if any surgery is scheduled.
• May affect results of some medical tests.
• Report any unusual bleeding to your doctor.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
-------------------------	-----------------------
Antacids*	Decreased ticlopidine effect.
Aspirin	Increased effects of both drugs.
Cimetidine	Increased ticlopidine effect.
Digoxin	Slightly decreased digoxin effect.
Theophylline	Increased theophylline effect.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Increased alcohol in blood. Avoid.
Beverages:	No proven problems.
Cocaine:	No proven problems.
Foods:	Best to take with foods to prevent
	stomach upset.
Marijuana:	No proven problems.
Tobacco:	No proven problems.