TESTOSTERONE & ESTRADIOL

Brand & Generic Names

Andrest	Estrand
Andro-Estro	Estra-Testrin
Andro/Fem	Menoject-L.A.
Androgyn L.A.	Neo-Pause
De-Comberol	Teev
Deladumone	T.E.-Ionate P.A.
Delatestadiol	Testadiate-Depo
depAndrogyn	Test-Estra-C
Depo-Testadiol	Test-Estro Cypionates
Depotestogen	TESTOSTERONE CYPIONATE &
Ditate DS	ESTRADIOL CYPIONATE
Duo-Cyp	TESTOSTERONE ENANTHATE &
Duo-Gen L.A.	ESTRADIOL VALERATE
Duogex LA	Testradiol
Duoval PA	Testradiol L.A.
Duratestrin	Valertest

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? Yes
• Drug class: Androgens-estrogens

Uses

• Prevents breast fullness in new mothers after childbirth.
• Relieves menopause symptoms such as unnecessary sweating, hot flashes, chills, faintness and dizziness.

Dosage & Usage Information

How to take:
Given by injection, deeply intramuscular.

When to take:
When directed.

If you forget a dose:
Check with your doctor.

What drug does:
Restores normal estrogen level in tissues.
Stimulates cells that produce male sex characteristics.
Replaces hormones lost due to deficiencies.
Stimulates red blood cell production.
Suppresses production of estrogen.

Time lapse before drug works:
10 to 20 days.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
Headache (severe), coordination loss, vision changes, chest pain, shortness of breath (sudden), speech slurring.

WHAT TO DO:

Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects

Life-threatening:

• In case of overdose, see Overdose section.
• Hives, black stool, Discontinue. Seek black or bloody vomit, emergency treatment. intense itching, weakness, loss of consciousness.

Common:

• Red or flushed face; rash; swollen, tender breasts.
• Depression, irritability, dizziness, confusion, acne or oily skin, enlarged clitoris, deepened voice, appetite loss, increased sex drive, unnatural hair growth, headache, constipation.

Infrequent:

• Nausea, vomiting, diarrhea, unusual vaginal bleeding or discharge, uncontrolled muscle movements.
• Swollen feet and ankles, migraine headache.

Rare:

• Jaundice, abdominal pain.
• Brown blotches on skin; hair loss; sore throat, fever, mouth sores.

Warnings & Precautions

Don't take if:

• You are allergic to any male hormone or any estrogen- containing drugs.
• You have impaired liver function.
• You have had blood clots, stroke or heart attack.
• You have unexplained vaginal bleeding.

Before you start, consult your doctor:

• If you might be pregnant or plan to become pregnant within 3 months.
• If you have heart disease, arteriosclerosis, diabetes, liver disease, high blood pressure, asthma, congestive heart failure, kidney disease or gallstones.
• If you have a high level of blood calcium.
• If you have had migraine headaches, epilepsy or porphyria.
• If you have had cancer of breast or reproductive organs, fibrocystic breast disease, fibroid tumors of the uterus or endometriosis.

Over age 60:

• May stimulate sexual activity.
• Can make high blood pressure or heart disease worse.
• Controversial. You and your doctor must decide if drug risks outweigh benefits.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.

Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:

• Increased growth of fibroid tumors of uterus.
• Possible kidney stones.
• Unnatural hair growth and deep voice in women.
• Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check pap smear, liver function, mammogram, complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit).
• Possible breast lumps, jaundice, sore throat, fever. If any of these occur, call your doctor.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
No problems expected.

Discontinuing:
You may need to discontinue estrogens periodically. Consult your doctor.

Others:

• In rare instances, may cause blood clot in lung, brain or leg. Symptoms are SUDDEN severe headache, coordination loss, vision change, chest pain, breathing difficulty, slurred speech, pain in legs or groin. Seek emergency treatment immediately.
• Will not increase strength in athletes.
• Carefully read the paper delivered with your prescription called "Information for the Patient."
• Don't smoke.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Anticoagulants*,	Increased effect of anticoagulant.
Anticonvulsants*,	Increased seizures.
Antidiabetics*,	Unpredictable increase or decrease
oral	in blood sugar.
Antifibrinolytic	Increased possibility of blood
agents*	clotting.
Carbamazepine	Increased seizures.
Chlorzoxazone	Decreased androgen effect.
Cholestyramine	Decreased cholestyramine effect.
Clofibrate	Decreased clofibrate effect.
Colestipol	Decreased colestipol effect.
Insulin	Unpredictable increase or decrease
	in blood sugar.
Nicotinic acid	Decreased nicotinic acid.
Oxyphenbutazone	Decreased androgen and estrogen
	effect.
Phenobarbital	Decreased androgen and estrogen
	effect.
Phenylbutazone	Decreased androgen and testosterone
	effect.
Primidone	Decreased estrogen and testosterone
	effect.
Rifampin	Decreased estrogen and testosterone
	effect.
Terazosin	Decreases effectiveness of
	terazosin.
Thyroid hormones*	Decreased thyroid effect.
Ursodiol	Decreased effect of ursodiol.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	None expected.
Beverages:	None expected.
Cocaine:	No proven problems.
Salt.	Excessive fluid retention (edema).
	Decrease salt intake while taking
	male hormones.
Marijuana:	Decreased blood levels of
	androgens. Possible menstrual
	irregularities and bleeding between
	periods.
Tobacco:	Increased risk of blood clots
	leading to stroke or heart attack.