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Brand & Generic Names

Apo-Sulfamethoxazole SMZ-TMP
Apo-Sulfatrim Sulfamethoprim
Bactrim Sulfamethoprim DS
Bactrim DS Sulfaprim
Bethaprim Sulfaprim DS
Cheragan w/TMP Sulfatrim
Cotrim Sulfatrim DS
Cotrim D.S. Sulfoxaprim
Co-trimoxazole Sulfoxaprim DS
Gantanol Sulmeprim
Gantanol DS Triazole
Novotrimel Triazole DS
Protrin Trimeth-Sulfa
Roubac Trisulfam
Septra Uroplus DS
Septra DS Uroplus SS

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Sulfa (sulfonamide)


    Treatment for urinary tract infections responsive to this drug.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid. Instructions to take on empty stomach mean 1 hour before or 2 hours after eating.
Liquid--Shake carefully before measuring.

When to take:
At the same times each day, evenly spaced.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Interferes with a nutrient (folic acid) necessary for growth and reproduction of bacteria. Will not attack viruses.

Time lapse before drug works:
2 to 5 days to affect infection.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Less urine, bloody urine, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Itchy skin, rash.
  • Headache, nausea, vomiting, diarrhea, appetite loss, skin sensitive to sun.


  • Red, peeling or blistering skin; sore throat; fever; swallowing difficulty; unusual bruising; aching joints or muscles; jaundice.
  • Dizziness, weakness, tiredness.


    Painful urination; low back pain; numbness, tingling, burning feeling in feet and hands, bloody urine, neck swelling.

Warnings & Precautions

Don't take if:
You are allergic to any sulfa* drug.

Before you start, consult your doctor:

  • If you are allergic to carbonic anhydrase inhibitors, oral antidiabetics or thiazide or loop diuretics.
  • If you are allergic by nature.
  • If you have liver or kidney disease.
  • If you have porphyria.
  • If you have developed anemia from use of any drug.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Don't give to infants younger than 1 month.

Prolonged use:

  • May enlarge thyroid gland.
  • You may become more susceptible to infections caused by germs not responsive to this drug.
  • Request frequent blood counts, liver and kidney function studies.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Avoid if you feel dizzy. Otherwise, no problems expected.

Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear.


  • Drink 2 quarts of liquid each day to prevent adverse reactions.
  • If you require surgery, tell anesthetist you take sulfa. Pentothal anesthesia should not be used.

Possible Interaction with Other Drugs

------------------------ -----------------------
Aminobenzoates Possible decreased sulfa effect.
Anticoagulants*, Increased anticoagulant effect.
Anticonvulsants*, Toxic effect on brain.
Aspirin Increased sulfa effect.
Calcium Decreased sulfa effect.
Clozapine Toxic effect on the central nervous
Hepatotoxic agents* Increased liver toxicity.
Isoniazid Possible anemia.
Mecamylamine Decreased antibiotic effect.
Methenamine Possible kidney blockage.
Methotrexate Increased methotrexate effect.
Oxyphenbutazone Increased sulfa effect.
Para-aminosalicylic Decreased sulfa effect.
Penicillins* Decreased penicillin effect.
Phenylbutazone Increased sulfa effect.
Probenecid Increased sulfa effect.
Sulfinpyrazone Increased sulfa effect.
Sulfonureas* May increase hypoglycemic action.
Trimethoprim Increased sulfa effect.
Zidovudine Increased risk of toxic effects of

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Increased alcohol effect.
Less than 2 quarts Kidney damage.
Cocaine: None expected.
Foods: None expected.
Marijuana: None expected.
Tobacco: None expected.

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