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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Antihypertensive, diuretic


  • Reduces high blood pressure.
  • Prevents fluid retention.
  • Treats hyperaldosteronism, hypokalemia, polycystic ovary syndrome, female hirsutism.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
1 dose a day--Take after breakfast.
More than 1 dose a day--Take last dose no later than 6 p.m.

If you forget a dose:
1 dose a day--Take as soon as you remember up to 12 hours late. If more than 12 hours, wait for next scheduled dose (don't double this dose).
More than 1 dose a day--Take as soon as you remember. Wait 6 hours for next dose.

What drug does:
Increases sodium and water excretion through increased urine production, decreasing body fluid and blood pressure.
Retains potassium.

Time lapse before drug works:
3 to 5 days.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Thirst, drowsiness, confusion, fatigue, weakness, nausea, vomiting, irregular heartbeat, excessive blood pressure drop.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


    Drowsiness or headache, thirst, nausea, vomiting, diarrhea, abdominal cramping, muscle cramps.


  • Confusion, irregular heartbeat, shortness of breath, constipation, breast tenderness, unusual sweating.
  • Numbness, tingling in hands or feet; menstrual irregularities; change in sex drive; dizziness; energy loss.


  • Rash or itchy skin, fever.
  • Deep voice in women, excess hair growth, voice change, enlarged clitoris in women.

Warnings & Precautions

Don't take if:

  • You are allergic to spironolactone.
  • You have impaired kidney function.
  • Your serum potassium level is high.

Before you start, consult your doctor:

  • If you have had kidney or liver disease.
  • If you have diabetes.
  • If you have menstrual abnormalities or breast enlargement.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:

  • Limit use to 2 to 3 weeks if possible.
  • Adverse reactions and side effects may be more frequent and severe than in younger persons.
  • Heat or fever can reduce blood pressure. May require dose adjustment.
  • Overdose and extended use may cause blood clots.

No proven harm to unborn child. Avoid if possible. Consult doctor.

No proven problems. Consult doctor.

Infants & children:
Use only under medical supervision.

Prolonged use:

  • Potassium retention with irregular heartbeat, unusual weakness and confusion.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check blood pressure, kidney function, ECG* and serum electrolytes.

Skin & sunlight:
Increased sensitivity to sunlight.

Driving, piloting or hazardous work:
Avoid if you feel drowsy. Otherwise, no problems expected.

Consult doctor about adjusting doses of other drugs.

No problems expected.

Possible Interaction with Other Drugs

------------------------ -----------------------
ACE inhibitors*: Possible excessive
captopril, enalapril, potassium in blood.
Amiloride Dangerous potassium retention.
Anticoagulants*, Possible decreased
oral anticoagulant effect.
Antihypertensives*, Increased antihypertensive
other effect.
Aspirin Decreased spironolactone effect.
Carteolol Increased antihypertensive effect.
Cyclosporine Possible excessive potassium in
Digitalis Decreased digitalis
preparations* effect.
Diuretics*, other Increased effect of both drugs.
Beneficial if needed and dose is
Laxatives* Reduced potassium levels.
Lithium Likely lithium toxicity.
Nicardipine Blood pressure drop. Dosages may
require adjustment.
Nimodipine Dangerous blood pressure drop.
Nitrates* Excessive blood pressure drop.
Potassium iodide May raise potassium level in blood
to toxic levels.
Potassium Dangerous potassium retention,
supplements* causing possible heartbeat
Salicylates* May decrease spironolactone effect.
Sodium bicarbonate Reduced high potassium levels.
Sotalol Increased antihypertensive effect.
Terazosin Decreases effectiveness of
Triamterene Dangerous potassium retention.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: None expected.
Low-salt milk. Possible potassium toxicity.
Cocaine: Increased risk of heart block and
high blood pressure.
Salt. Don't restrict unless directed by
Salt substitutes. Possible potassium toxicity.
Marijuana: Increased thirst, fainting.
Tobacco: None expected.

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