SELEGILINE

Brand & Generic Names

Eldepryl	Movergan
Jumex	Procythol
Jumexal	SD Deprenyl
Juprenil

Basic Information

All the information in this chart applies only when selegiline is given with other drugs that treat Parkinson's disease.
• Habit forming? No
• Prescription needed? Yes
• Available as generic? No
• Drug class: Antidyskinetic

Uses

• Treats Parkinson's disease (paralysis agitans) when given with levodopa or the combination of levodopa and carbidopa.
• Treats mental depression when taken alone.

Dosage & Usage Information

How to take:
Tablets--Swallow with liquid. If you can't swallow whole, crumble tablet and take with liquid or food. Instructions to take on empty stomach mean 1 hour before or 2 hours after eating.

When to take:
Usually taken at breakfast and lunch to minimize nausea or insomnia. Don't take after mid-afternoon.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Inhibits action of monoamine oxidase Type B (MAO B), a major chemical enzyme in the brain. Doses higher than recommended can cause high blood pressure.

Time lapse before drug works:
2 hours.

Don't take with:
Any foods containing tyramine, such as cheese; wine; beer; non-alcoholic beer; liqueurs; yeast extracts; bean pods; pickled or smoked fish, meat, chicken, turkey or other poultry; fermented sausage (summer sausage, salami, pepperoni); bologna; overripe fruit; caffeine.
Any other medicines (including over-the-counter drugs such as cough and cold medicines, laxatives, antacids, diet pills, nose drops or vitamins) without consulting your doctor.
Study Interaction Section.

Overdose

SYMPTOMS:
Mouth-opening difficulty; neck and heel muscle spasm; sweating; irregular, fast heartbeat; reflexes hyperactive; cold or clammy skin; chest pain; agitation; fainting; seizures; coma. Symptoms can develop 12 to 48 hours after ingestion.

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• If patient is unconsciousness and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
• See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

• In case of overdose, see Overdose section.
• Severe chest pain, Seek emergency treatment. enlarged pupils, heartbeat irregularities, severe nausea and vomiting, stiff neck.

Common:

• Mood changes, unusual or uncontrolled body movements, hallucinations, headache, lip smacking, difficult urination.
• Abdominal pain, dizziness, dry mouth, insomnia, mild nausea.

Infrequent:

• Chest pain, heartbeat irregularities, wheezing, swollen feet, speech difficulty, bloody or black stools.
• Constipation; anxiety; tiredness; eyelid spasm; unpleasant taste; blurred vision; leg pain; ears ringing; chills; skin rash; lips or mouth burning; drowsiness; frequent, decreased urination.

Rare:

Weight loss, heartburn, jaw clenching or teeth gnashing, impaired memory, uncontrolled body movements.

Warnings & Precautions

Don't take if:
You are allergic to selegiline.

Before you start, consult your doctor:
If you have a past medical history of peptic ulcer.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons. You may need smaller doses for shorter periods of time.

Pregnancy:
Risk to unborn child outweighs benefits. Don't use.

Breast-feeding:
Unknown if drug passes into milk. Consult doctor.

Infants & children:
Not recommended.

Prolonged use:
Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit), stomach x-rays.

Skin & sunlight:
Increased sensitivity to ultraviolet rays from sun or sunlamps. Avoid overexposure.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes.

Discontinuing:
No special problems expected.

Others:

• Avoid sudden rises from lying-down or sitting positions.
• Advise any doctor or dentist whom you consult that you take this medicine.
• May affect results in some medical tests.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Caffeine (high doses)	Can cause same symptoms as
	tyramine-containing foods*. (See
	"Don't take with" information.)
Fluoxetine	Increased risk of mental status
	changes.
Levodopa	Increased risk of adverse
	reactions.
Meperdine	Possibly severe drop in blood
	pressure. Avoid.
Narcotics,*	Severe toxic reaction leading to
	seizures, coma, and/or death.
Sertraline	Increased depressive effects of
	both drugs.
Sumatriptan	Adverse effects unknown. Avoid.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Can cause severe toxicity. Avoid.
Drinks containing large	Can cause severe toxicity. Avoid.
Cocaine:	High blood pressure, rapid
	heartbeat. Avoid.
Tyramine-containing*.	Severe toxicity, perhaps
(See "Don't take with"	leading to death. CAREFULLY avoid.
Marijuana:	Rapid heart rate. Avoid.
Tobacco:	Rapid heart rate. Avoid.