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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Antigout


  • Treatment for chronic gout.
  • Increases blood levels of penicillins and cephalosporins.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
At the same time each day.

If you forget a dose:
Take as soon as you remember up to 12 hours late. If more than 12 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Forces kidneys to excrete uric acid.
Reduces amount of penicillin excreted in urine.

Time lapse before drug works:
May require several months of regular use to prevent acute gout.

Don't take with:
Non-prescription drugs containing aspirin or caffeine.
Any other medicine without consulting your doctor or pharmacist.


Breathing difficulty, severe nervous agitation, vomiting, seizures, convulsions, delirium, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


    Headache, appetite loss, nausea, vomiting.


  • Blood in urine, low back pain, worsening gout.
  • Dizziness, flushed face, itchy skin.
  • Painful or frequent urination, sore gums.


    Sore throat, fever and chills; difficult breathing; unusual bleeding or bruising; red, painful joint; jaundice; foot, leg or face swelling.

Warnings & Precautions

Don't take if:

  • You are allergic to any uricosuric*.
  • You have acute gout.
  • Patient is younger than 2.

Before you start, consult your doctor:

  • If you have had kidney stones or kidney disease.
  • If you have a peptic ulcer.
  • If you have bone marrow or blood cell disease.
  • If you are undergoing chemotherapy for cancer.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Studies inconclusive on harm to unborn child. Animal studies show fetal abnormalities. Decide with your doctor whether drug benefits justify risk to unborn child.

No proven problems. Consult doctor.

Infants & children:
Not recommended.

Prolonged use:

  • Possible kidney damage.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check serum uric acid, urine uric acid.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Avoid if you feel dizzy. Otherwise, no problems expected.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.

If signs of gout attack develop while taking medicine, consult doctor.

Possible Interaction with Other Drugs

------------------------ -----------------------
Allopurinol Increased effect of each drug.
Anticoagulants*, Increased anticoagulant effect.
Aspirin Decreased probenecid effect.
Bismuth Decreased effect of
subsalicylate probenecid.
Cefixime Increased cefixime effect.
Cephalosporins* Increased cephalosporin effect.
Ciprofloxacin May cause kidney dysfunction.
Dapsone Increased dapsone effect. Increased
Diclofenac Increased diclofenac effect.
Diuretics, thiazide* Decreased probenecid effect.
Hypoglycemics*, Increased hypoglycemic effect.
Indomethacin Increased adverse effects of
Ketoprofen Increased risk of ketoprofen toxicity.
Loracarbef Increased loracarbef effect.
Methotrexate Increased methotrexate toxicity.
Nitrofurantoin Increased effect of nitrofurantoin.
Non-steroidal anti- Increased toxic risk.
Para-aminosalicylic Increased effect of para-
acid aminosalicylic acid.
Penicillins* Enhanced penicillin effect.
Pyrazinamide Decreased probenecid effect.
Salicylates* Decreased probenecid effect.
Sodium benzoate May reduce effect of sodium
& sodium phenylacetate benzoate & sodium phenylacetate.
Sulfa drugs* Slows elimination. May cause
harmful accumulation of sulfa.
Thioguanine More likelihood of toxicity of
both drugs.
Zidovudine Increased zidovudine toxicity risk.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Decreased probenecid effect.
Caffeine drinks. Loss of probenecid effectiveness.
Cocaine: None expected.
Foods: None expected.
Marijuana: Daily use--Decreased probenecid
Tobacco: None expected.

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