PANCREATIN, PEPSIN, BILE SALTS, HYOSCYAMINE,

Brand & Generic Names

Donnazyme

Basic Information

• Habit forming? Yes
• Prescription needed? Yes
• Available as generic? No
• Drug class: Digestant, sedative, anticholinergic

Uses

• Replaces deficient digestive enzymes.
• Sometimes used to relieve indigestion.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with food or liquid.

When to take:
With or after meals.

If you forget a dose:
Skip it and resume schedule. Don't double dose.

What drug does:
Blocks nerve impulses at parasympathetic nerve endings, preventing smooth muscle contraction and gland secretions.

Time lapse before drug works:
30 to 60 minutes.

Don't take with:
Any medicine that will decrease mental alertness or reflexes, such as alcohol, other mind-altering drugs, cough/cold medicines, antihistamines, allergy medicine, sedatives, tranquilizers (sleeping pills or "downers") barbiturates, seizure medicine, narcotics, other prescription medicine for pain, muscle relaxants, anesthetics.
See Interaction Section and consult doctor.

Overdose

SYMPTOMS:
Hallucinations, excitement, breathing difficulty, irregular heartbeat (too fast or too slow), fainting, collapse, coma.

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

In case of overdose, see Overdose section.

Common:

• Constipation, decreased sweating, headache.
• Drowsiness, dry mouth, frequent urination.

Infrequent:

• Blurred vision.
• Diminished sex drive, swallowing difficulty, sensitivity to light, insomnia.

Rare:

• Jaundice; unusual bleeding or bruising; swollen feet and ankles; abdominal pain; sore throat, fever, mouth sores; rash; hives; vomiting; joint pain; eye pain; diarrhea; blood in urine.
• Unusual tiredness.

Warnings & Precautions

Don't take if:

• You are allergic to any of the drugs in this combination.
• You have trouble with stomach bloating, difficulty emptying your bladder completely, narrow-angle glaucoma, severe ulcerative colitis, porphyria.

Before you start, consult your doctor:

• If you have open-angle glaucoma, angina, chronic bronchitis or asthma, liver disease, hiatal hernia, enlarged prostate, myasthenia gravis, epilepsy, kidney or liver damage, anemia, chronic pain.
• If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.

Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Use only under medical supervision.

Prolonged use:

• Chronic constipation, possible fecal impaction.
• May cause addiction, anemia, chronic intoxication.
• May lower body temperature, making exposure to cold temperatures hazardous.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Discontinuing:

• May be unnecessary to finish medicine. Follow doctor's instructions.
• If you develop withdrawal symptoms of hallucinations, agitation or sleeplessness after discontinuing, call doctor right away.

Others:

• Potential for abuse.
• Enzyme deficiencies probably better treated with identified separate substances rather than a mixture of components.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Amantadine	Increased atropine effect.
Antacids*	Decreased absorption of
	scopolamine.
Anticholinergics*,	Increased anticholinergic effect.
Anticoagulants*,	Decreased anticoagulant effect.
Antidepressants,	Decreased antidepressant effect.
tricyclic (TCA)*	Possible dangerous oversedation.
Antidiabetics*,	Increased phenobarbital effect.
Antihistamines*	Increased atropine effect.
Aspirin	Decreased aspirin effect.
Attapulgite	Decreased anticholinergic effect.
Beta-adrenergic	Decreased effect of
blockers*	beta-adrenergic blocker.
Buclizine	Increased scopolamine effect.
Central nervous system	Increased CNS depression.
Contraceptives*,	Decreased contraceptive
oral	effect.
Cortisone drugs*	Decreased cortisone effect.
Digitalis	Possible decreased absorption of
	digitalis.
Disopyramide	Increased atropine effect.
Dronabinol	Increased phenobarbital effect.
Griseofulvin	Decreased griseofulvin effect.
Haloperidol	Increased internal eye pressure.
Indapamide	Increased indapamide effect.
Ketoconazole	Decreased ketoconazole effect.
MAO inhibitors*	Increased atropine effect.
Meperidine	Increased atropine effect.
Methylphenidate	Increased atropine effect.
Mind-altering	Dangerous sedation. Avoid.
Narcotics*	Dangerous sedation. Avoid.
Nitrates*	Increased internal eye pressure.
Nizatidine	Increased nizatidine effect.
Non-steroidal	Decreased anti-inflammatory
anti-inflammatory	effects.
Orphenadrine	Increased atropine effect.
Phenothiazines*	Increased atropine effect.
Pilocarpine	Loss of pilocarpine effect in
	glaucoma treatment.
Potassium	Possible intestinal ulcers with
supplements*	oral potassium tablets.
Quinidine	Increased quinidine and scopolamine
	effect.
Sedatives*	Dangerous sedation. Avoid.
Sleep inducers*	Dangerous sedation. Avoid.
Tranquilizers*	Dangerous sedation. Avoid.
Valproic acid	Increased phenobarbital effect.
Vitamin C	Decreased atropine effect. Avoid
	large doses of vitamin C.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Possible fatal oversedation. Avoid.
Beverages:	None expected.
Cocaine:	Excessively rapid heartbeat. Avoid.
Foods:	None expected.
Marijuana:	Excessive sedation, drowsiness and
	dry mouth.
Tobacco:	May increase stomach acidity,
	decreasing the effectiveness of
	the drug. Avoid.