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Brand & Generic Names

Apo-Nitrofurantoin Nephronex
Cyantin Nifuran
Furadantin Nitrex
Furalan Nitrofan
Furaloid Nitrofor
Furan Nitrofuracot
Furanite Novofuran
Furantoin Ro-Antoin
Furatine Sarodant
Furaton Trantoin
Macrobid Urotoin

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Antimicrobial


    Treatment for urinary-tract infections.

Dosage & Usage Information

How to take:
Tablet or capsule--Swallow with food or milk to lessen stomach irritation. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food.
Extended-release capsule--Swallow with liquid. Do not open capsule.
Liquid--Shake well and take with food. Use a measuring spoon to ensure accuracy.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Prevents susceptible bacteria in the urinary tract from growing and multiplying.

Time lapse before drug works:
1 to 2 weeks.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Nausea, vomiting, abdominal pain, diarrhea.


    Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects


    Hives, rash, intense Seek emergency itching, faintness treatment immediately. soon after a dose (anaphylaxis).


  • Diarrhea, appetite loss, nausea, vomiting, chest pain, cough, difficult breathing, chills or unexplained fever, abdominal pain.
  • Rusty colored or brown urine.


  • Rash, itchy skin, numbness, tingling or burning of face or mouth, fatigue, weakness.
  • Dizziness, headache, drowsiness, paleness (in children), discolored teeth (from liquid form).



Warnings & Precautions

Don't take if:

  • You are allergic to nitrofurantoin.
  • You have impaired kidney function.
  • You drink alcohol.

Before you start, consult your doctor:

  • If you are prone to allergic reactions.
  • If you are pregnant and within 2 weeks of delivery.
  • If you have had kidney disease, lung disease, anemia, nerve damage, or G6PD* deficiency (a metabolic deficiency).
  • If you have diabetes. Drug may affect urine sugar tests.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Risk to unborn child outweighs drug benefits, especially in last month of pregnancy. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Don't give to infants younger than 1 month. Use only under medical supervision for older children.

Prolonged use:

  • Chest pain, cough, shortness of breath.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check liver function, lung function.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Avoid if you feel dizzy or drowsy. Otherwise, no problems expected.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.

Periodic blood counts, liver-function tests, and chest X-rays recommended.

Possible Interaction with Other Drugs

------------------------ -----------------------
Dapsone Increased risk of adverse effect
on blood cells.
Didanosine Increased risk of pancreatitis and
peripheral neuropathy.
Hemolytics*, other Increased risk of toxicity.
Isoniazid Increased risk of liver damage.
Nalidixic acid Decreased nitrofurantoin effect.
Neurotoxic medicines* Increased risk of damage to nerve
Phenobarbital Decreased nitrofurantoin effect.
Probenecid Increased nitrofurantoin effect.
Sulfinpyrazone Possible nitrofurantoin toxicity.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Possible disulfiram reaction*.
Beverages: None expected.
Cocaine: No proven problems.
Foods: None expected.
Marijuana: None expected.
Tobacco: None expected.

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