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Brand & Generic Names

222 Drocade and Aspirin
292 Emcodeine
293 Empirin with Codeine
692 Endodan
Anacin with Codeine Lortab ASA
Ancasal Margesic A-C
ASPIRIN & CODEINE Novopropoxyn Compound
Azdone Oxycodan
Coryphen with Codeine Percodan
Cotanal 65 Percodan-Demi
Damason-P Pro Pox Plus
Darvon with A.S.A. Roxiprin
Darvon-N with A.S.A. Synalgos-DC
Darvon-N Compound Talwin Compound
Doraphen Compound 65 Talwin Compound-50
Doxaphene Compound

Basic Information

  • Habit forming? Yes
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Narcotic, analgesic, anti-inflammatory (non-steroidal)


    Reduces pain, fever, inflammation.

Dosage & Usage Information

How to take:
Tablet or capsule--Swallow with liquid. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food.

When to take:
When needed. No more often than every 4 hours.

If you forget a dose:
Take as soon as you remember. Wait 4 hours for next dose.

What drug does:
Affects hypothalamus, the part of the brain which regulates temperature by dilating small blood vessels in skin.
Prevents clumping of platelets (small blood cells) so blood vessels remain open.
Decreases prostaglandin effect.
Suppresses body's pain messages.
Reduces sensitivity of brain's cough-control center.

Time lapse before drug works:
30 minutes.

Don't take with:
Tetracyclines. Space doses 1 hour apart.
Any other medicine without consulting your doctor or pharmacist.


Ringing in ears; nausea; vomiting; dizziness; fever; deep sleep; slow breathing; slow pulse; flushed, warm skin; constricted pupils; hallucinations; convulsions; coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.

Possible Adverse Reactions or Side Effects


  • Hives, rash, intense Seek emergency itching, faintness treatment immediately. soon after a dose (anaphylaxis); difficulty breathing.
  • Lump (caused by blood Discontinue. Seek emergency clot in vein) or pain treatment. over blood vessel; cold hands, feet; seizures; pin point pupils.


  • Headache (severe), slow heartbeat, excitement, vomiting of blood.
  • Dizziness, red or flushed face, ringing in ears, unusual tiredness, frequent urination, heartburn, indigestion, fever, hallucinations, constipation.


    Abdominal pain or cramps, vomiting.


  • Change in vision; black, bloody or tarry stool; blood in urine; jaundice; mental confusion; irregular breathing; face swelling.
  • Depression, blurred vision.

Warnings & Precautions

Don't take if:

  • You are allergic to any narcotic or subject to any substance abuse.
  • You have a peptic ulcer of stomach or duodenum or a bleeding disorder.

Before you start, consult your doctor:

  • If you have impaired liver or kidney function, asthma or nasal polyps.
  • If you have had stomach or duodenal ulcers, gout.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:

  • More likely to be drowsy, dizzy, unsteady or constipated. Use only if absolutely necessary.
  • More likely to cause hidden bleeding in stomach or intestines. Watch for dark stools.

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk and may harm child. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:

  • Causes psychological and physical dependence (addiction).
  • Kidney damage. Periodic kidney function test recommended.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

May be unnecessary to finish medicine. Follow doctor's instructions. Notify doctor of any withdrawal symptoms such as gooseflesh, irritability, insomnia, yawning, weakness, large eye pupils.


  • Aspirin can complicate surgery; illness; pregnancy, labor and delivery.
  • Urine tests for blood sugar may be inaccurate.

Possible Interaction with Other Drugs

------------------------ -----------------------
Acebutolol Decreased antihypertensive effect
of acebutolol.
ACE inhibitors*: Decreased effect of
captopril, enalapril, ACE inhibitors.
Allopurinol Decreased allopurinol effect.
Antacids* Decreased aspirin effect.
Anticoagulants* Increased anticoagulant effect.
Abnormal bleeding.
Antidepressants* Increased sedative effect.
Antidiabetics*, oral Low blood sugar.
Aspirin, other Likely aspirin toxicity.
Bumetanide Possible aspirin toxicity.
Carteolol Increased narcotic effect.
Dangerous sedation.
Cortisone drugs* Increased cortisone effect. Risk of
ulcers and stomach bleeding.
Ethacrynic acid Possible aspirin toxicity.
Furosemide Possible aspirin toxicity. May
decrease furosemide effect.
Gold compounds* Increased likelihood of kidney
Indomethacin Risk of stomach bleeding and
Methotrexate Increased methotrexate effect.
Minoxidil Decreased minoxidil effect.
Narcotics*, other Increased narcotic effect.
Nitrates* Excessive blood pressure drop.
Non-steroidal Risk of stomach
anti-inflammatory bleeding and ulcers.
Propranolol Decreased aspirin effect.
Rauwolfia alkaloids* Decreased aspirin effect.
Salicylates*, other Likely aspirin toxicity.
Sedatives* Increased sedative effect.
Selegiline Severe toxicity characterized by
breathing difficulties, seizures,
Sleep inducers* Increased sedative effect.
Sotalol Increased narcotic effect.
Dangerous sedation.
Spironolactone Decreased spironolactone effect.
Sulfinpyrazone Decreased sulfinpyrazone effect.
Terfenadine Possible excessive sedation. May
conceal symptoms of aspirin
overdose, such as ringing in ears.
Ticlopidine Decreased effect of both drugs.
Tranquilizers* Increased sedative effect.
Valproic acid May increase valproic acid effect.
Vitamin C Possible aspirin
(large doses) toxicity.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Possible stomach irritation and
bleeding. Increases alcohol's
intoxicating effect. Avoid.
Beverages: None expected.
Cocaine: Increased toxic effects of cocaine.
Foods: None expected.
Marijuana: Impairs physical and mental
performance. Avoid.
Tobacco: None expected.

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