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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Antimicrobial


    Treatment for urinary tract infections.

Dosage & Usage Information

How to take:
Tablet--Swallow with food or milk to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food.
Liquid--Take with liquid or food.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Destroys bacteria susceptible to nalidixic acid.

Time lapse before drug works:
1 to 2 weeks.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Lethargy, stomach upset, behavioral changes, hyperglycemia, psychosis, convulsions and stupor.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    Hives, rash, intense Seek emergency itching, faintness treatment immediately. soon after a dose (anaphylaxis).


    Rash; itchy skin; decreased, blurred or double vision; halos around lights or excess brightness; changes in color vision; nausea; vomiting; diarrhea.


  • Dizziness, drowsiness, sensitivity to sun, headache.
  • Dark urine, hallucinations, mood changes.


    Paleness, sore throat or fever, severe abdominal pain, pale stool, unusual bleeding or bruising, jaundice, fatigue, weakness, seizures, psychosis, joint pain, numbness or tingling in hands or feet.

Warnings & Precautions

Don't take if:

  • You are allergic to nalidixic acid.
  • You have a seizure disorder (epilepsy, convulsions).

Before you start, consult your doctor:

  • If you plan to become pregnant within medication period.
  • If you have or have had kidney or liver disease.
  • If you have impaired circulation of the brain (hardened arteries).
  • If you have Parkinson's disease.
  • If you have diabetes (drug may affect urine sugar tests).

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Risk to unborn child outweighs drug benefits. Don't use, especially during first 3 months.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:
Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit), liver function, kidney function.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Avoid if you feel drowsy, dizzy or have vision problems. Otherwise, no problems expected.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.

Periodic blood counts and liver and kidney function tests recommended.

Possible Interaction with Other Drugs

------------------------ -----------------------
Antacids* Decreased absorption of nalidixic
Anticoagulants, Increased anti-
oral* coagulant effect.
Calcium supplements* Decreased effect of nalidixic acid.
Nitrofurantoin Decreased effect of nalidixic acid.
Probenecid Decreased effect of nalidixic acid.
Vitamin C Increased effect of
(in large doses) nalidixic acid.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Impaired alertness, judgment and
Beverages: None expected.
Cocaine: Impaired judgment and coordination.
Foods: None expected.
Marijuana: Impaired alertness, judgment and
Tobacco: None expected.

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