Diseases Symptoms Drugs Injuries Surgeries Vitamins Pediatric Symptoms
  home         about us         support center         contact us         terms of service         site map


Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: MAO (monoamine oxidase) inhibitor, antidepressant


  • Treatment for depression.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Inhibits nerve transmissions in brain that may cause depression.

Time lapse before drug works:
4 to 6 weeks for maximum effect.

Don't take with:
Non-prescription diet pills, nose drops, medicine for asthma, cough, cold or allergy, or medicine containing caffeine or alcohol.
Foods containing tyramine*.
Any other medicine without consulting your doctor or pharmacist.


Restlessness, agitation, excitement, fever, confusion, dizziness, heartbeat irregularities, hallucinations, sweating, breathing difficulties, insomnia, irritability, convulsions, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Fatigue, weakness.
  • Dizziness when changing position, restlessness, tremors, dry mouth, constipation, difficult urination, blurred vision, "sweet tooth."


  • Fainting, enlarged pupils.
  • Severe headache, chest pain.
  • Hallucinations, insomnia, nightmares, diarrhea, rapid or pounding heartbeat, swollen feet or legs, joint pain.
  • Diminished sex drive.


    Rash, nausea, vomiting, stiff neck, jaundice, fever, increased sweating, dark urine, slurred speech.

Warnings & Precautions

Don't take if:

  • You are allergic to any MAO inhibitor.
  • You have heart disease, congestive heart failure, heart-rhythm irregularities or high blood pressure.
  • You have liver or kidney disease.

Before you start, consult your doctor:

  • If you are alcoholic.
  • If you have had a stroke.
  • If you have diabetes, epilepsy, asthma, overactive thyroid, schizophrenia, Parkinson's disease, adrenal-gland tumor.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:
Not recommended.

Risk to unborn child outweighs benefits. Don't use, especially during first 3 months.

Safety not established. Consult doctor.

Infants & children:
Not recommended.

Prolonged use:

  • May be toxic to liver.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check blood pressure, liver function.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes.


  • Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear.
  • Follow precautions regarding foods, drinks and other medicines for 2 weeks after discontinuing.
  • Adverse symptoms caused by this medicine may occur even after discontinuation. If you develop any of the symptoms listed under Overdose, notify your doctor immediately.


  • May affect blood-sugar levels in patients with diabetes.
  • Fever may indicate that MAO inhibitor dose requires adjustment.

Possible Interaction with Other Drugs

------------------------ -----------------------
Amphetamines* Blood pressure rise to life-
threatening level.
Anticholinergics* Increased anticholinergic effect.
Anticonvulsants* Changed seizure pattern.
Antidepressants, Blood pressure rise to
tricyclic (TCA)* life-threatening level. Possible
fever, convulsions, delirium.
Antidiabetics, Excessively low blood
oral and insulin* sugar.
Antihypertensives* Excessively low blood pressure.
Beta-adrenergic Possible blood
blockers* pressure rise if MAO inhibitor is
discontinued after simultaneous use
with acebutolol.
Bupropion Increased risk of bupropion
Buspirone Very high blood pressure.
Caffeine Irregular heartbeat or high blood
Carbamazepine Fever, seizures. Avoid.
Central nervous system Excessive depressant action.
(CNS) depressants*
Clozapine Toxic effect on the central nervous
Cyclobenzaprine Fever, seizures. Avoid.
Dextromethorphan Very high blood pressure.
Diuretics* Excessively low blood pressure.
Ephedrine Increased blood pressure.
Ethinamate Dangerous increased effects of
ethinamate. Avoid combining.
Fluoxetine Increased depressant effects of
both drugs.
Furazolidine Sudden, severe increase in
blood pressure.
Guanadrel High blood pressure.
Guanethidine Blood pressure rise to life-
threatening level.
Guanfacine May increase depressant effects of
either drug.
Hypoglycemics*, Increased hypoglycemic effect.
Indapamide Increased indapamide effect.
Insulin Increased hypoglycemic effect.
Leucovorin High alcohol content of leucovorin
may cause adverse effects.
Levodopa Sudden, severe blood pressure rise.
MAO inhibitors* High fever, convulsions, death.
Maprotiline Dangerous blood pressure rise.
Methyldopa Sudden, severe blood pressure rise.
Methylphenidate Increased blood pressure.
Methyprylon Increased sedative effect, perhaps
to dangerous level. Avoid.
Nabilone Greater depression of central
nervous system.
Narcotic analgesics* Severe high blood pressure.
Paroxetine Can cause a life-threatening reaction.
Phenothiazines* Possible increased phenothiazine
Phenylpropanolamine Increased blood pressure.
Pseudoephedrine Increased blood pressure.
Sertraline Increased depressive effects
of both drugs.
Sympathomimetics* Blood pressure rise to life-
threatening level.
Trazodone Increased risk of mental status
Tryptophan Increased blood pressure.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Increased sedation to dangerous
Caffeine drinks. Irregular heartbeat or high blood
Drinks containing Blood pressure rise to
tyramine* life-threatening level.
Cocaine: Overstimulation. Possibly fatal.
Foods containing Blood pressure rise to
tyramine* life-threatening level.
Marijuana: Overstimulation. Avoid.
Tobacco: No proven problems.

Dserun mollit anim id est laborum. Lorem ipsum and sunt in culpa qui officias deserunt mollit. Excepteur plus sint occaecat the best cupidatat nonr proident, sunt in culpa qui officia deserunt mollit anim id est laborum. September 24, 2004
read more


Excepteur plus sint occaecat the best cupidatat nonr proident, sunt in culpa qui officia deserunt mollit.
Support forums
Help desk
home       about us      affiliates     contact us       terms of service      

© 2005 All right reserved