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Brand & Generic Names

Apo-Metronidazole Metro I.V.
Flagyl Neo-Metric
Flagyl I.V. Novonidazol
Flagyl I.V. RTU PMS Metronidazole
Metizol Protostat
Metric 21 Satric
Metrogel Trikacide

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Antiprotozoal


  • Treatment for infections susceptible to metronidazole, such as trichomoniasis and amebiasis.
  • Topical--Treats acne rosacea (adult acne).
  • Vaginal--Treats vaginal infections.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food. Topical gel--Apply thin layer to involved area.

When to take:
At the same times each day.
Gel--Apply twice a day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Kills organisms causing the infection.

Time lapse before drug works:
Begins in 1 hour. May require regular use for 10 days to cure infection.

Don't take with:
Non-prescription medicines containing alcohol.
Any other medicine without consulting your doctor or pharmacist.


Weakness, nausea, vomiting, diarrhea, confusion, seizures.


    Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Appetite loss, nausea, abdominal pain, diarrhea, vomiting.
  • Unpleasant taste.


  • Dizziness; headache; rash; hives; skin redness; itchy skin; mouth irritation, soreness or infection; sore throat; fever.
  • Vaginal irritation, discharge, dryness; fatigue; weakness.
  • Constipation.


  • Mood change; unsteadiness; numbness, tingling, weakness or pain in hands or feet.
  • Metallic taste.

Warnings & Precautions

Don't take if:

  • You are allergic to metronidazole.
  • You have had a blood-cell or bone-marrow disorder.

Before you start, consult your doctor:

  • If you plan to become pregnant within medication period.
  • If you have a brain or nervous-system disorder.
  • If you have liver or heart disease.
  • If you drink alcohol.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Risk to unborn child outweighs drug benefits. Manufacturer advises against use during first 3 months and only limited use after that. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Use in children for amoeba infection only under close medical supervision.

Prolonged use:
Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check for giardiasis in stools.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Avoid if you feel dizzy or unsteady. Otherwise, no problems expected.

Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear.

Avoid alcohol 12 hours before and at least 24 hours after treatment period with metronidazole.

Possible Interaction with Other Drugs

------------------------ -----------------------
Anticoagulants*, Increased anticoagulant effect.
oral Possible bleeding or bruising.
Cimetidine Prolongs increased serum levels.
Didanosine Increased risk of peripheral
Disulfiram Disulfiram reaction*. Avoid.
Nizatidine Increased effect and toxicity of
Oxytetracycline Decreased metronidazole effect.
Phenobarbital Decreased effect of metronidazole.
Phenytoin Decreased effect of metronidazole.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Possible disulfiram reaction*.
Avoid alcohol in ANY form or
Beverages: None expected.
Cocaine: Decreased metronidazole effect.
Foods: None expected.
Marijuana: None expected.
Tobacco: None expected.

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