Brand & Generic Names
- Habit forming? Yes
- Prescription needed? Yes
- Available as generic? No
- Drug class: Vasoconstrictor
Prevents migraine and other recurring vascular headaches. Not
for acute attack.
Dosage & Usage Information
How to take:
Tablet--Swallow with liquid or with food to lessen stomach
irritation. If you can't swallow whole, crumble tablet and take
with liquid or food.
When to take:
At the same times each day.
If you forget a dose:
Don't take missed dose. Wait for next
scheduled dose (don't double this dose).
What drug does:
Blocks the action of serotonin, a chemical that constricts blood
Time lapse before drug works:
About 3 weeks.
Don't take with:
Any other medicine without consulting your doctor or pharmacist.
Nausea, vomiting, abdominal pain, severe diarrhea,
lack of coordination, extreme thirst.
WHAT TO DO:
Overdose unlikely to threaten life. If person takes much larger
amount than prescribed, call doctor, poison-control center or
hospital emergency room for instructions.
Possible Adverse Reactions or Side Effects
In case of overdose, see Overdose section.
- Itchy skin.
- Nausea, vomiting,
or tingling of
weakness, abdominal pain.
- Anxiety, agitation,
unusually fast or
slow heartbeat, dizziness.
- Change in vision,
- Extreme thirst, chest
of breath, fever, pale
or swollen extremities,
leg cramps, lower
back pain, side or
groin pain, appetite
loss, joint and muscle
pain, rash, facial flush.
- Painful or difficult
- Weight change,
Warnings & Precautions
Don't take if:
- You are allergic to any antiserotonin*.
- You plan to become pregnant within medication period.
- You have an infection.
- You have a heart or blood vessel disease.
- You have a chronic lung disease.
- You have a collagen (connective tissue) disorder.
- You have impaired liver or kidney function.
Before you start, consult your doctor:
- If you have been allergic to any ergot preparation.
- If you have had a peptic ulcer.
Over age 60:
Adverse reactions and side effects may be more frequent and
severe than in younger persons.
Manufacturer suggests risk to unborn child outweighs drug
benefits, even though studies are inconclusive. Consult doctor.
Drug probably passes into milk. Avoid drug or discontinue
nursing until you finish medicine. Consult doctor for advice on
maintaining milk supply.
Infants & children:
- May cause fibrosis, a condition in which scar tissue is
deposited on heart valves, in lung tissue, blood vessels and
internal organs. After 6 months, decrease dose over 2 to 3
weeks. Then discontinue for at least 2 months for re-evaluation.
- Talk to your doctor about the need for follow-up medical
examinations or laboratory studies to check retroperitoneal
Skin & sunlight:
No problems expected.
Driving, piloting or hazardous work:
Avoid if you feel drowsy or dizzy. Otherwise, no problems
- Don't discontinue without consulting doctor. Dose may require
gradual reduction if you have taken drug for a long time. Doses
of other drugs may also require adjustment.
- Probably should discontinue drug if you don't improve after 3
- Periodic laboratory tests for liver function and blood counts
- Potential for abuse.
- Some products contain tartrazine dye. Avoid, especially if you
are allergic to aspirin.
Possible Interaction with Other Drugs
||Unpredictable increased or
||decreased effect of either drug.
||Decreased narcotic effect.
Possible Interaction with Other Substances
||None expected. However, alcohol may
||trigger a migraine headache.
||Decreased methysergide effect.
||May make headache worse.
||None expected. Avoid foods to which
||you are allergic.
||No proven problems.
||Blood-vessel constriction. Makes