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Brand & Generic Names

Methergine Methylergometrine

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Ergot preparation (uterine stimulant)


    Retards excessive post-delivery bleeding.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation.

When to take:
At the same times each day.

If you forget a dose:
Don't take missed dose and don't double next one. Wait for next scheduled dose.

What drug does:
Causes smooth-muscle cells of uterine wall to contract and surround bleeding blood vessels of relaxed uterus.

Time lapse before drug works:
Tablets--20 to 30 minutes.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Vomiting, diarrhea, weak pulse, low blood pressure, dyspnea, angina, convulsions.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


    Nausea, vomiting, severe lower abdominal menstrual-like cramps.


  • Confusion, ringing in ears, diarrhea, muscle cramps.
  • Unusual sweating.


    Sudden, severe headache; shortness of breath; chest pain; numb, cold hands and feet.

Warnings & Precautions

Don't take if:
You are allergic to any ergot preparation.

Before you start, consult your doctor:

  • If you have coronary artery or blood vessel disease.
  • If you have liver or kidney disease.
  • If you have high blood pressure.
  • If you have postpartum infection.

Over age 60:
Not recommended.

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:
Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check blood pressure, ECG*.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

May be unnecessary to finish medicine. Follow doctor's instructions.

Drug should be used for short time only following childbirth or miscarriage.

Possible Interaction with Other Drugs

------------------------ -----------------------
Antianginals* Possible vasospasm (peripheral
and cardiac)
Ergot preparations, Increased methyl-
other* ergonovine effect.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: None expected.
Beverages: None expected.
Cocaine: None expected.
Foods: None expected.
Marijuana: None expected.
Tobacco: Decreased methylergonovine effect.
Don't smoke.

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