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Brand & Generic Names

PMS Dopazide

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Antihypertensive, diuretic (thiazide)


  • Controls, but doesn't cure, high blood pressure.
  • Reduces fluid retention (edema).

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Relaxes walls of small arteries to decrease blood pressure.
Forces sodium and water excretion, reducing body fluid.
Reduced body fluid and relaxed arteries lower blood pressure.

Time lapse before drug works:
Continual use for 2 to 4 weeks may be necessary to determine effectiveness.

Don't take with:
Non-prescription drugs without consulting doctor.
Any other medicine without consulting your doctor or pharmacist.


Drowsiness; exhaustion; cramps; weakness; stupor; confusion; slow, weak pulse; coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    Irregular heartbeat, Discontinue. Seek weak pulse. emergency treatment.


    Depression, nightmares, drowsiness, weakness, stuffy nose, dry mouth, swollen feet and ankles, dizziness, sedation, increased thirst, muscle cramps.


  • Fast heartbeat, change in vision, abdominal pain, nervousness.
  • Insomnia, nausea, vomiting, diarrhea, headache, constipation.


    Rash, jaundice, dark urine, chills, breathing difficulty, hives, sore throat, fever, mouth sores, sore or "black" tongue, severe abdominal pain, decreased mental activity, memory impairment, facial paralysis, slow heartbeat, chest pain.

Warnings & Precautions

Don't take if:

  • You are allergic to any thiazide diuretic drug.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Before you start, consult your doctor:

  • If you are allergic to any sulfa drug.
  • If you have gout, liver, pancreas or kidney disorder.

Over age 60:

  • Increased susceptibility to dizziness, unsteadiness, fainting, falling.
  • Drug can produce or intensify Parkinson's disease.

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:

  • May cause anemia.
  • Severe edema (fluid retention).
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit), blood pressure, liver function.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.


  • Hot weather and fever may cause dehydration and drop in blood pressure. Dose may require temporary adjustment. Weigh daily and report any unexpected weight decreases to your doctor.
  • May cause rise in uric acid, leading to gout.
  • May cause blood-sugar rise in diabetics.
  • Avoid heavy exercise, exertion, sweating.

Possible Interaction with Other Drugs

------------------------ -----------------------
Acebutolol Increased antihypertensive effect.
Dosages of both drugs may require
ACE inhibitors*: Possible excessive potassium in blood.
Allopurinol Decreased allopurinol effect.
Amphetamines* Decreased methyldopa effect.
Anticoagulants*, Increased anticoagulant effect.
Antidepressants, Dangerous changes in blood pressure.
tricyclic (TCA)* Avoid combination unless under
medical supervision.
Antihypertensives* Increased antihypertensive effect.
Barbiturates* Increased hydrochlorothiazide
Carteolol Increased antihypertensive effect.
Cholestyamine Decreased hydrochlorothiazide
Cortisone drugs* Excessive potassium loss that
causes dangerous heart rhythms.
Dapsone Increased risk of adverse effect
on blood cells.
Didanosine Increased risk of pancreatitis.
Digitalis Excessive potassium loss that causes
preparations* causes dangerous heart rhythms.
Diuretics, thiazide* Increased effect of both drugs.
Haloperidol Increased sedation, possibly
Indapamide Increased diuretic effect.
Levodopa Increased effect of both drugs.
Lithium Increased lithium effect.
MAO inhibitors* Dangerous blood pressure changes.
Nabilone Greater depression of central
nervous system.
Nicardipine Blood pressure drop. Dosages may
require adjustment.
Nimodipine Dangerous blood pressure drop.
Nitrates* Excessive blood pressure drop.
Norepinephrine Decreased methyldopa effect.
Phenoxybenzanine Urinary retention.
Phenylephrine Decreased methyldopa effect.
Phenylpropanolamine Decreased methyldopa effect.
Potassium Decreased potassium effect.
Propranolol Increased blood pressure (rarely).
Sertraline Increased depressive effects of
both drugs.
Sotalol Increased antihypertensive effect.
Terazosin Decreased terazosin effect.
Tolbutamide Increased tolbutamide effect.
Zinc supplements Increased need for zinc.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Increased sedation. Excessive blood
pressure drop. Avoid.
Beverages: None expected.
Cocaine: Increased risk of heart block and
high blood pressure.
Licorice. Excessive potassium loss that
causes dangerous heart rhythms.
Marijuana: May increase blood pressure.
Tobacco: Possible increased blood pressure.

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