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Brand & Generic Names

Hip-Rex Urex
Hiprex Urised
Mandelamine Urisedamine
Prosed Uro-phosphate
Trac Tabs 2X Uroquid

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Anti-infective (urinary)


    Suppresses chronic urinary-tract infections.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food.
Liquid form--Use a measuring spoon to ensure correct dose.
Granules--Dissolve dose in 4 oz. of water. Drink all the liquid.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 8 hours late. If more than 8 hours, wait for next scheduled dose (don't double this dose).

What drug does:
A chemical reaction in the urine changes methenamine into formaldehyde, which destroys certain bacteria.

Time lapse before drug works:
Continual use for 3 to 6 months.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Bloody urine, weakness, deep breathing, stupor, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Rash.
  • Nausea, difficult urination.


  • Blood in urine.
  • Burning on urination, lower back pain.


    None expected.

Warnings & Precautions

Don't take if:

  • You are allergic to methenamine.
  • You have a severe impairment of kidney or liver function.
  • The urine cannot or should not be acidified (check with your doctor).

Before you start, consult your doctor:

  • If you have had kidney or liver disease.
  • If you plan to become pregnant within medication period.
  • If you have had gout.

Over age 60:
Don't exceed recommended dose.

Studies inconclusive on harm to unborn child. Avoid if possible, especially first 3 months. Consult doctor.

Drug passes into milk in small amounts. Consult doctor.

Infants & children:
Use only under medical supervision.

Prolonged use:
No problems expected.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear.

Requires an acid urine to be effective. Eat more protein foods, cranberries, cranberry juice with vitamin C, plums, prunes.

Possible Interaction with Other Drugs

------------------------ -----------------------
Antacids* Decreased methenamine effect.
Carbonic anhydrase Decreased methenamine effect.
Citrates* Decreases effects of methenamine.
Diuretics, thiazide* Decreased urine acidity.
Sodium bicarbonate Decreased methenamine effect.
Sulfadoxine and Increased risk of kidney toxicity.
Sulfa drugs* Possible kidney damage.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Possible brain depression. Avoid or
use with caution.
Milk and other Decreased methenamine effect.
Cocaine: None expected.
Citrus, cranberries, Increased methenamine effect.
Marijuana: Drowsiness, muscle weakness or
blood pressure drop.
Tobacco: None expected.

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