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Brand & Generic Names

Phenylalanine Mustard

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Antineoplastic


  • Treatment for some kinds of cancer.
  • Suppresses immune response after transplant and in immune disorders.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid after light meal. Don't drink fluids with meals. Drink extra fluids between meals. Avoid sweet or fatty foods.

When to take:
At the same time each day.

If you forget a dose:
Take as soon as you remember. Don't ever double dose.

What drug does:
Inhibits abnormal cell reproduction. May suppress immune system.

Time lapse before drug works:
Up to 6 weeks for full effect.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Bleeding, chills, fever, collapse, stupor, seizure.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Unusual bleeding or bruising, mouth sores with sore throat, chills and fever, black stools, sores in mouth and lips, menstrual irregularities, back pain.
  • Hair loss, joint pain.
  • Nausea, vomiting, diarrhea (unavoidable), tiredness, weakness.


  • Skin rash.
  • Mental confusion, shortness of breath.
  • Cough.


    Jaundice, swelling in feet or legs.

Warnings & Precautions

Don't take if:

  • You have had hypersensitivity to alkylating antineoplastic drugs.
  • Your physician has not explained serious nature of your medical problem and risks of taking this medicine.

Before you start, consult your doctor:

  • If you have gout.
  • If you have had kidney stones.
  • If you have active infection.
  • If you have impaired kidney or liver function.
  • If you have taken other antineoplastic drugs or had radiation treatment in last 3 weeks.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Consult doctor. Risk to child is significant.

Drug passes into milk. Don't nurse.

Infants & children:
Use only under special medical supervision at center experienced in anticancer drugs.

Prolonged use:

  • Adverse reactions more likely the longer drug is required.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit), kidney function.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Some side effects may follow discontinuing. Report to doctor blurred vision, convulsions, confusion, persistent headache, fever or chills, blood in urine, unusual bleeding.


  • May cause sterility.
  • May increase chance of developing leukemia.

Possible Interaction with Other Drugs

------------------------ -----------------------
Antigout drugs* Decreased antigout effect.
Antineoplastic Increased effect
drugs, other* of all drugs (may be beneficial).
Bone marrow Increased risk of bone marrow toxicity.
Chloramphenicol Increased likelihood of toxic
effects of both drugs.
Clozapine Toxic effect on bone marrow.
Lovastatin Increased heart and kidney damage.
Probenecid Increased likelihood of bone marrow
Sulfinpyrazone Increased likelihood of bone marrow
Tiopronin Increased risk of toxicity to bone
Vaccines, live Increased likelihood of toxicity or
or killed reduced effectiveness of vaccine.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: May increase chance of intestinal
Beverages: No problems expected.
Cocaine: Increases chance of toxicity.
Foods: Reduces irritation in stomach.
Marijuana: No problems expected.
Tobacco: Increases lung toxicity.

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