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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Anticancer treatment adjunct


  • Treats colorectal cancer when used in combination with fluorouracil.
  • Treats malignant melanoma after surgical removal when there is no evidence of spread to organs other than the skin.

Dosage & Usage Information

How to take:
Tablet: Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
At the same time each day, according to instructions on prescription label.

If you forget a dose:
Don't take until you notify your doctor.

What drug does:
Acts to help restore the immune system. May activate T-cell lymphocytes and other white cells. Also elevates mood.

Time lapse before drug works:
1-1/2 to 2 hours.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


None expected.


    Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects


    Fever, muscle aches, Seek emergency treatment. headache, cough, hoarseness, sore throat, painful or difficult urination, low back or side pain.


  • Diarrhea, metallic taste, nausea, joint or muscle pain, skin rash, insomnia, mental depression, nightmares, sleepiness or tiredness, increased dental problems.
  • Hair loss.


    Mouth, tongue and lip sores.


    Unsteady gait while walking; blurred vision; confusion; tremors; tingling or numbness in hands, feet or face; seizures; smacking and puckering of lips; uncontrolled tongue movements.

Warnings & Precautions

Don't take if:
You are allergic to levamisole.

Before you start, consult your doctor:

  • If you take other drugs for cancer.
  • If you have an active infection.
  • If you have a seizure disorder.
  • If you have allergies to other medications.

Over age 60:
No special problems expected.

Adequate studies not yet done. Consult your doctor.

Delay breast feeding until you no longer take levamisole.

Infants & children:
Effect not documented. Consult your family doctor or pediatrician.

Prolonged use:
No special problems expected.

Skin & sunlight:
No special problems expected.

Driving, piloting or hazardous work:
No special problems expected.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.


  • Advise any doctor or dentist whom you consult that you take this medicine.
  • Defer dental treatments until your blood count is normal. Pay particular attention to dental hygiene. You may be subject to additional risk of oral infection, delayed healing and bleeding.
  • Avoid aspirin. May increase risk of internal bleeding.
  • Avoid constipation. May increase risk of internal bleeding.

Possible Interaction with Other Drugs

------------------------- -----------------------
Anticoagulants* Increased risk of bleeding.
Aspirin Increased risk of bleeding.
Bone marrow Increased risk of bone
depressants* marrow depression.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Increased risk of gastritis
and internal bleeding.
Beverages: None expected.
Cocaine: Increased risk of
mental disturbances. Avoid.
Foods: None expected.
Marijuana: None expected.
Tobacco: None expected.

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