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Brand & Generic Names

INH PMS Isoniazid
Isotamine Rifamate
Laniazid Rimifon
Nydrazid Tubizid

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Antitubercular


    Kills tuberculosis germs.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid to lessen stomach irritation.
Syrup--Follow label directions.

When to take:
At the same time each day.

If you forget a dose:
Take as soon as you remember up to 12 hours late. If more than 12 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Interferes with TB germ metabolism. Eventually destroys the germ.

Time lapse before drug works:
3 to 6 months. You may need to take drug as long as 2 years.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Difficult breathing, convulsions, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Muscle pain and pain in joints, tingling or numbness in extremities, jaundice.
  • Confusion, unsteady walk.


  • Swollen glands, nausea, indigestion, diarrhea, vomiting, appetite loss.
  • Dizziness.


  • Rash, fever, impaired vision, anemia with fatigue, weakness, fever, sore throat, unusual bleeding or bruising.
  • Breast enlargement or discomfort.

Warnings & Precautions

Don't take if:
You are allergic to isoniazid.

Before you start, consult your doctor:

  • If you plan to become pregnant within medication period.
  • If you are allergic to athionamide, pyrazinamide or nicotinic acid.
  • If you drink alcohol.
  • If you have liver or kidney disease.
  • If you have epilepsy, diabetes or lupus.

Over age 60:
Adverse reactions and side effects, especially jaundice, may be more frequent and severe than in younger persons. Kidneys may be less efficient.

No proven harm to unborn child. Avoid if possible, especially in the first 6 months of pregnancy. Consult doctor about use in last 3 months.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Use only under medical supervision.

Prolonged use:

  • Numbness and tingling of hands and feet.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check liver function, eyes.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Avoid if you feel dizzy. Otherwise, no problems expected.

Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear.


  • Diabetic patients may have false blood-sugar tests.
  • Periodic liver-function tests and laboratory blood studies recommended.
  • Prescription for vitamin B-6 (pyridoxine) recommended to prevent nerve damage.

Possible Interaction with Other Drugs

------------------------ -----------------------
Acetaminophen Increased risk of liver damage.
(aluminum-containing) Decreased absorption of isoniazid.
Anticholinergics* May increase pressure within
Anticoagulants* Increased anticoagulant effect.
Antidiabetics* Increased antidiabetic effect.
Antihypertensives* Increased antihypertensive effect.
Carbamazepine Increased risk of liver damage.
Cycloserine Increased risk of central nervous
system effects.
Didanosine Increased risk of peripheral neuropathy.
Disulfiram Increased effect of disulfiram.
Laxatives* Decreased absorption and effect of
Hepatotoxics* Increased risk of liver damage.
Ketoconazole Increased risk of liver damage.
Narcotics* Increased narcotic effect.
Niacin Decreased niacin effect.
Phenytoin Increased phenytoin effect.
Pyridoxine Decreased chance of
(Vitamin B-6) nerve damage in extremities.
Rifampin Increased isoniazid toxicity to
Sedatives* Increased sedative effect.
Stimulants* Increased stimulant effect.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Increased incidence of liver
Beverages: None expected.
Cocaine: None expected.
Fish or Cheshire Red or itching skin, fast heartbeat.
cheese, fish. Seek emergency treatment.
Marijuana: No interactions expected, but
marijuana may slow body's recovery.
Tobacco: No interactions expected, but
tobacco may slow body's recovery.

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