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Brand & Generic Names

Lozide Lozol

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Antihypertensive, diuretic


  • Controls, but doesn't cure, high blood pressure.
  • Reduces fluid retention (edema) caused by conditions such as heart disorders.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation.

When to take:
At the same times each day, usually at bedtime.

If you forget a dose:
Bedtime dose--If you forget your once-a- day bedtime dose, don't take it more than 3 hours late. Never double dose.

What drug does:
Forces kidney to excrete more sodium and causes excess salt and fluid to be excreted.

Time lapse before drug works:
2 hours for effect to begin. May require 1 to 4 weeks for full effects.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Nausea, vomiting, diarrhea, very dry mouth, thirst, weakness, excessive fatigue, very rapid heart rate, weak pulse.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Excessive tiredness or weakness, muscle cramps.
  • Frequent urination.


    Insomnia, mood change, dizziness on changing position, headache, excessive thirst, diarrhea, appetite loss, nausea, dry mouth, decreased sex drive.


  • Weak pulse.
  • Itching, rash, hives, irregular heartbeat.

Warnings & Precautions

Don't take if:

  • You are allergic to indapamide or to any sulfa drug or thiazide diuretic*.
  • You have severe kidney disease.

Before you start, consult your doctor:

  • If you have severe kidney disease.
  • If you have diabetes.
  • If you have gout.
  • If you have liver disease.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.
  • If you have lupus erythematosus.
  • If you are pregnant or plan to become pregnant.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Risk to unborn child outweighs drug benefits. Don't use.

Unknown effect on child. Consult doctor.

Infants & children:
Use only under close medical supervision.

Prolonged use:
Request laboratory studies for blood sugar, BUN, uric acid and serum electrolytes (potassium and sodium).

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.

No problems expected.

Possible Interaction with Other Drugs

------------------------ -----------------------
ACE inhibitors*: Decreased blood
captopril, enalapril, pressure. Possible
lisinopril excessive potassium in blood.
Allopurinol Decreased allopurinol effect.
Amiodarone Increased risk of heartbeat
irregularity due to low potassium.
Amphotericin B Increased potassium.
Antidepressants, Dangerous drop in
tricyclic (TCA)* blood pressure.
Antidiabetic agents, Increased blood sugar.
Antihypertensives, Increased anti-
other* hypertensive effect.
Barbiturates* Increased indapamide effect.
Beta-adrenergic Increased effect of
blockers* indapamide.
Calcium supplements* Increased calcium in blood.
Carteolol Increased antihypertensive effect.
Cholestyramine Decreased indapamide effect.
Colestipol Decreased indapamide effect.
Cortisone drugs* Excessive potassium loss that may
cause dangerous heart rhythms.
Digitalis Excessive potassium
preparations* loss that may cause dangerous heart
Diuretics, thiazide* Increased effect of thiazide
Indomethacin Decreased indapamide effect.
Lithium High risk of lithium toxicity.
MAO inhibitors* Increased indapamide effect.
Nicardipine Dangerous blood pressure drop.
Dosages may require adjustment.
Nimodipine Dangerous blood pressure drop.
Opiates* Weakness and faintness when arising
from bed or chair.
Probenecid Decreased probenecid effect.
Sotalol Increased antihypertensive effect.
Terazosin Decreased effectiveness of

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Dangerous blood pressure drop.
Beverages: No problems expected.
Cocaine: Increased risk of heart block and
high blood pressure.
Licorice. Excessive potassium loss that may
cause dangerous heart rhythms.
Marijuana: Reduced effectiveness of
indapamide. Avoid.
Tobacco: Reduced effectiveness of
indapamide. Avoid.

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