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Brand & Generic Names

Esimil Ismelin-Esidrix

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Antihypertensive, diuretic


  • Controls, but doesn't cure, high blood pressure.
  • Reduces fluid retention (edema).

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
At the same time each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Forces sodium and water secretion, reducing body fluid.
Displaces norepinephrine--hormone necessary to maintain small blood vessel tone. Blood vessels relax and high blood pressure drops.

Time lapse before drug works:
Regular use for several weeks may be necessary to determine effectiveness.

Don't take with:
Non-prescription drugs containing alcohol without consulting doctor.
Any other medicine without consulting your doctor or pharmacist.


Cramps, weakness, drowsiness, blurred vision, weak pulse, severe blood pressure drop, fainting, cold and sweaty skin, loss of consciousness, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    Chest pain, shortness Discontinue. Seek of breath, irregular emergency treatment. heartbeat.


  • Slow heartbeat, swollen feet and ankles, fatigue, weakness.
  • Dizziness, stuffy nose, dry mouth, diarrhea, diminished sex drive.


  • Mood change, rash or hives, blurred vision, drooping eyelids, muscle pain or tremors.
  • Increased nighttime urination, abdominal pain, vomiting, nausea, headache, weakness.
  • Impotence, nighttime urination, hair loss.


  • Decreased white blood cells causing sore throat, fever; jaundice.
  • Weight gain or loss.

Warnings & Precautions

Don't take if:

  • You are allergic to any thiazide diuretic drug or guanethidine.
  • You have taken MAO inhibitors within 2 weeks.

Before you start, consult your doctor:

  • If you are allergic to any sulfa drug.
  • If you have gout, asthma, liver, pancreas or kidney disorder, peptic ulcer or chronic acid indigestion.
  • If you have had stroke or heart disease.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons, especially dizziness and excessive potassium loss.

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:

  • Due to drug's cumulative effect, dose will require adjustment to prevent wide fluctuations in blood pressure.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.


  • Hot weather and fever may cause dehydration and drop in blood pressure. Dose may require temporary adjustment. Weigh daily and report any unexpected weight decreases to your doctor.
  • May cause rise in uric acid, leading to gout.
  • May cause blood-sugar rise in diabetics.

Possible Interaction with Other Drugs

------------------------ -----------------------
Allopurinol Decreased allopurinol effect.
Amphetamines* Decreased guanethidine effect.
Antidepressants, Dangerous drop in
tricyclic (TCA)* blood pressure. Avoid combination
unless under medical supervision.
Antihistamines* Decreased guanethidine effect.
Barbiturates* Increased hydrochlorothiazide
Beta-adrenergic Increased antihypertensive
blockers* effect. Dosages of both drugs may
require adjustments.
Carteolol Increased antihypertensive effect.
Cholestyramine Decreased hydrochlorothiazide
Contraceptives, Decreased guanethidine
oral* effect.
Cortisone drugs* Excessive potassium loss that
causes dangerous heart rhythms.
Digitalis Excessive potassium
preparations* loss that causes dangerous heart
Diuretics, thiazide* Increased thiazide and guanethidine
Haloperidol Decreased guanethidine effect.
Indapamide Possible increased effects of both
drugs. When monitored carefully,
combination may be beneficial in
controlling hypertension.
Insulin Increased insulin effect.
Lithium Increased lithium effect.
MAO inhibitors* Increased hydrochlorothiazide
Minoxidil Dosage adjustments may be necessary
to keep blood pressure at proper
Nicardipine Blood pressure drop. Dosages may
require adjustment.
Nimodipine Dangerous blood pressure drop.
Nitrates* Excessive blood pressure drop.
Oxprenolol Increased antihypertensive effect.
Dosages of both drugs may require
Phenothiazines* Decreased guanethidine effect.
Potassium Decreased potassium
supplements* effect.
Probenecid Decreased probenecid effect.
Sotalol Increased antihypertensive effect.
Terazosin Decreases effectiveness of

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Use caution. Decreases blood
Carbonated drinks. Use sparingly. Sodium content
increases blood pressure.
Cocaine: Raises blood pressure. Avoid.
Spicy or Avoid if subject to indigestion
acid foods. or peptic ulcer.
Licorice. Excessive potassium loss that
causes dangerous heart rhythms.
Marijuana: Effect on blood pressure
Tobacco: Possible blood pressure rise.

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