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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Antihypertensive


    Controls, but doesn't cure, high blood pressure.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Relaxes muscle cells of small arteries.
Slows heartbeat.

Time lapse before drug works:
1 hour.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Severe dizziness, slow heartbeat, unusual tiredness or weakness, pinpoint pupils, fainting, coma.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • If patient is unconscious and not breathing, give mouth-to- mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    In case of overdose, see Overdose section.


  • Dry mouth, drowsiness.
  • Insomnia, weakness.


  • Irregular heartbeat, shakiness in hands.
  • Dizziness, appetite loss, nausea, vomiting, painful or difficult urination, headache.


    Decreased sex drive.

Warnings & Precautions

Don't take if:
You are allergic to any sympathomimetic drug.

Before you start, consult your doctor:

  • If you have blood disease.
  • If you have heart disease.
  • If you have liver disease.
  • If you have diabetes or overactive thyroid.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons. Hot weather may cause need to reduce dosage.

Risk to unborn child outweighs drug benefits. Don't use.

Unknown effect. Consult doctor.

Infants & children:
Not recommended.

Prolonged use:
Side effects tend to diminish. Request uric-acid and kidney- function studies periodically.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Avoid if you feel dizzy; otherwise, no problems expected.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment. Abruptly discontinuing may cause anxiety, chest pain, salivation, headache, abdominal cramps, fast heartbeat, increased sweating, tremors, insomnia.


  • Stay away from high-sodium foods. Lose weight if you are overweight.
  • May interfere with the accuracy of some medical tests.

Possible Interaction with Other Drugs

------------------------ -----------------------
ACE inhibitors*: Possible excessive
captopril, enalapril, potassium in blood.
Antihypertensives, Decreases blood
other* pressure more than either alone.
May be beneficial, but requires
dosage adjustment.
Beta-blockers* Blood pressure control more
Central nervous system Increased brain depression. Avoid.
Clozapine Toxic effect on the central nervous
Diuretics* Decreases blood pressure more than
either alone. May be beneficial,
but requires dosage adjustment.
Ethinamate Dangerous increased effects of
ethinamate. Avoid combining.
Fluoxetine Increased depressant effects of
both drugs.
Guanfacine May increase depressant effects of
either drug.
Leucovorin High alcohol content of leucovorin
may cause adverse effects.
Methyprylon Increased sedative effect, perhaps
to dangerous level. Avoid.
Nabilone Greater depression of central
nervous system.
Nicardipine Blood pressure drop. Dosages may
require adjustment.
Nimodipine Dangerous blood pressure drop.
Sertraline Increased depressive effects of
both drugs.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Oversedation. Avoid.
Caffeine. Overstimulation. Avoid.
Cocaine: Overstimulation. Avoid.
Salt. Decrease salt intake to increase
beneficial effects of guanabenz.
Marijuana: Overstimulation. Avoid.
Tobacco: Decreased guanabenz effect.

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