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ERGOTAMINE, BELLADONNA & PHENOBARBITAL


Brand & Generic Names

Bellergal
Bellergal-S
Bellergal Spacetabs


Basic Information

  • Habit forming? Yes
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Analgesic, antispasmodic, vasoconstrictor

Uses

  • Reduces anxiety or nervous tension (low dose).
  • Prevents vascular headaches.

Dosage & Usage Information

How to take:
Tablet or extended-release tablet--Swallow with liquid, or let dissolve under tongue.
Lie down in quiet, dark room after taking.

When to take:
At first sign of vascular or migraine headache.

If you forget a dose:
Take as soon as you remember. Wait 4 hours for next dose.

What drug does:
Constricts blood vessels in the head.
Blocks nerve impulses at parasympathetic nerve endings, preventing muscle contractions and gland secretions of organs involved.

Time lapse before drug works:
15 to 30 minutes.

Don't take with:
Non-prescription drugs without consulting doctor.


Overdose

SYMPTOMS:
Tingling, cold extremities; muscle pain; nausea; vomiting; diarrhea; cold skin; rapid and weak pulse; severe numbness of extremities; confusion; dilated pupils; rapid pulse and breathing; dizziness; fever; hallucinations; slurred speech; agitation; flushed face; convulsions; coma.

WHAT TO DO:

  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

    In case of overdose, see Overdose section.

Common:

  • Flushed skin, fever, drowsiness, bloating, depression, frequent urination.
  • Constipation, dizziness, drowsiness, "hangover" effect, increased frequency or severity of headaches.

Infrequent:

  • Swollen feet and ankles, numbness or tingling in hands or feet, cold hands and feet, rash.
  • Nasal congestion, altered taste.

Rare:

    Jaundice, weak legs, swallowing difficulty, dry mouth, increased sensitivity to sunlight, nausea, vomiting, decreased sweating.

Warnings & Precautions

Don't take if:

  • You are allergic to any barbiturate, tartrazine dye, anticholinergic or ergot preparation.
  • You have porphyria, trouble with stomach bloating, difficulty emptying your bladder completely, narrow-angle glaucoma, severe ulcerative colitis, enlarged prostate.

Before you start, consult your doctor:

  • If you have epilepsy; kidney, thyroid or liver damage; anemia; chronic pain; open-angle glaucoma; angina; fast heartbeat; heart problems; high blood pressure; hardening of the arteries; vein problems; chronic bronchitis; asthma; hiatal hernia; enlarged prostate; myasthenia gravis; peptic ulcer; an infection.
  • If you plan to become pregnant within medication period.
  • If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.

Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:

  • May cause addiction, anemia, chronic intoxication.
  • May lower body temperature, making exposure to cold temperatures hazardous.
  • Chronic constipation, possible fecal impaction.
  • Cold skin, muscle pain, gangrene of hands and feet. This medicine not intended for uninterrupted use.

Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or sunlamp.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Discontinuing:
May be unnecessary to finish medicine. Follow doctor's instructions. If you develop withdrawal symptoms of hallucinations, agitation or sleeplessness after discontinuing, call doctor right away.

Others:

  • Impaired blood circulation can lead to gangrene in intestines or extremities. Never exceed recommended dose.
  • May affect results in some medical tests.

Possible Interaction with Other Drugs

GENERIC NAME COMBINED EFFECT
------------------------ -----------------------
Amantadine Increased belladonna effect.
Amphetamines* Dangerous blood pressure rise.
Anticholinergics, Increased belladonna
other* effect.
Anticoagulants*, Decreased anti-
oral coagulant effect.
Anticonvulsants* Changed seizure patterns.
Antidepressants, Decreased anti-
tricyclics (TCA)* depressant effect. Possible
dangerous oversedation.
Antidiabetics*, Increased pheno-
oral barbital effect.
Antihistamines* Dangerous sedation. Avoid.
Aspirin Decreased aspirin effect.
Beta-adrenergic Narrowed arteries in
blockers* heart if taken in large doses.
Contraceptives*, Decreased contraceptive
oral effect.
Cortisone drugs* Decreased cortisone effect.
Increased internal eye pressure.
Digitoxin Decreased digitoxin effect.
Doxycycline Decreased doxycycline effect.
Dronabinol Increased effect of drugs.
Ephedrine Dangerous blood pressure rise.
Epinephrine Dangerous blood pressure rise.
Erythromycin Decreased ergotamine effect.
Griseofulvin Decreased griseofulvin effect.
Guanethidine Decreased belladonna effect.
Haloperidol Increased internal eye pressure.
Indapamide Increased indapamide effect.
MAO inhibitors* Increased belladonna and
phenobarbital effect.
Meperidine Increased belladonna effect.
Methylphenidate Increased belladonna effect.
Metoclopramide May decrease metoclopramide effect.
Mind-altering Dangerous sedation.
drugs* Avoid.
Narcotics* Dangerous sedation. Avoid.
Nitrates* Increased internal eye pressure.
Nitroglycerin Decreased nitroglycerin effect.
Orphenadrine Increased belladonna effect.
Pain relievers* Dangerous sedation. Avoid.
Phenothiazines* Increased belladonna effect.
Pilocarpine Loss of pilocarpine effect in
glaucoma treatment.
Potassium Possible intestinal ulcers with
supplements* oral potassium tablets.
Quinidine Increased belladonna effect.
Reserpine Decreased belladonna effect.
Sedatives* Dangerous sedation. Avoid.
Sleep inducers* Dangerous sedation. Avoid.
Sumatriptan Increased vasoconstriction. Delay
24 hours between drugs.
Tranquilizers* Dangerous sedation. Avoid.
Troleandomycin Increased adverse reactions of
ergotamine.
Valproic acid Increased phenobarbital effect.
Vitamin C Decreased belladonna effect. Avoid
large doses of vitamin C.


Possible Interaction with Other Substances

INTERACTS WITH COMBINED EFFECT
--------------- ---------------
Alcohol: Possible fatal oversedation. Avoid.
Beverages: None expected.
Cocaine: Excessively rapid heartbeat. Avoid.
Foods: None expected.
Marijuana: Drowsiness and dry mouth, excessive
sedation. Avoid.
Tobacco: None expected.



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