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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Antihyperlipidemic


    Lowers blood cholesterol and low-density lipoprotein in patients who don't respond to low-fat diet and weight loss alone.

Dosage & Usage Information

How to take:
Tablets--Swallow with liquid. If you can't swallow whole, crumble tablet and take with liquid or food. Instructions to take on empty stomach mean 1 hour before or 2 hours after eating.

When to take:
According to your doctor's instructions.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Increases breakdown of LDL (low-density lipoprotein).

Time lapse before drug works:
1 to 2 months.

Don't take with:
Any other medicines (including over-the-counter drugs such as cough and cold medicines, laxatives, antacids, diet pills, caffeine, nose drops or vitamins) without consulting your doctor.


None expected.


    Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects


    None expected.


  • Tremor, headache, irritability, insomnia.
  • Appetite change, diarrhea, leg cramps, menstrual irregularities, fever, heat sensitivity, unusual sweating, weight loss.


    Hives, rash, vomiting, chest pain, rapid and irregular heartbeat, shortness of breath.


    None expected.

Warnings & Precautions

Don't take if:

  • You have had a heart attack within 6 weeks.
  • You have no thyroid deficiency, but want to use this to lose weight.

Before you start, consult your doctor:

  • If you have heart disease or high blood pressure.
  • If you have diabetes.
  • If you have Addison's disease, have had adrenal gland deficiency or use epinephrine, ephedrine or isoproterenol for asthma.

Over age 60:
More sensitive to thyroid hormone. May need smaller doses.

Considered safe if for thyroid deficiency only.

Present in milk. Considered safe if dose is correct.

Infants & children:
Use only under medical supervision.

Prolonged use:

  • No problems expected, if dose is correct.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check serum cholesterol and triglycerides.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.


  • Digestive upsets, tremors, cramps, nervousness, insomnia or diarrhea may indicate need for dose adjustment.
  • Advise any doctor or dentist whom you consult that you take this medicine.
  • May affect results in some medical tests.
  • Stay on a low-fat diet.

Possible Interaction with Other Drugs

Amphetamines* Increased amphetamine effect.
Anticoagulants, oral* Increased anticoagulant effect.
Antidepressants, Increased antidepressant effect.
tricyclic (TCA)* Irregular heartbeat.
Antidiabetics* Antidiabetic may require
Aspirin (large doses, Increased dextrothyroxine effect.
Barbiturates* Decreased barbiturate effect.
Beta-adrenergic blockers* Possible decreased beta blockers
Cholestyramine Decreased dextrothyroxine effect.
Colestipol Decreased dextrothyroxine effect.
Contraceptives, Decreased dextrothyroxine effect.
Cortisone drugs* Requires dose adjustment to prevent
cortisone deficiency.
Digitalis preparations* Decreased digitalis effect.
Ephedrine Increased ephedrine effect.
Epinephrine Increased epinephrine effect.
Estrogens* Decreased dextrothyroxine effect.
Methylphenidate Increased methylphenidate effect.
Phenytoin Possible decreased dextrothyroxine

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: None expected.
Beverages: None expected.
Cocaine: Excess stimulation. Avoid.
Soybeans. Heavy consumption interferes with
thyroid function.
Marijuana: None expected.
Tobacco: None expected.

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