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Brand & Generic Names

Cyclomen Danocrine

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Gonadotropin inhibitor


    Treatment of endometriosis, fibrocystic breast disease, angioneurotic edema except in pregnant women, gynecomastia, infertility, excessive menstruation, precocious puberty.

Dosage & Usage Information

How to take:
Capsule--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, open capsule and take with liquid or food.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember (don't double dose).

What drug does:
Partially prevents output of pituitary follicle-stimulating hormone and lutenizing hormone reducing estrogen production.

Time lapse before drug works:
2 to 3 months to treat endometriosis.
1 to 2 months to treat other disorders.

Don't take with:
Birth control pills.
Any other medicine without consulting your doctor or pharmacist.


None expected.


    Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects


    None expected.


    Menstrual irregularities.


  • Unnatural hair growth in women, nosebleeds, bleeding gums, sore throat and chills.
  • Dizziness; deepened voice; hoarseness; flushed or red skin; muscle cramps; enlarged clitoris; decreased testicle size; vaginal burning, itching; swollen feet; decreased breast size, increased or decreased sex drive.
  • Headache, acne, weight gain, vision changes.


    Jaundice, flushing, sweating, vaginitis, rash, nausea, vomiting, constipation, abdominal pain.

Warnings & Precautions

Don't take if:

  • You become pregnant.
  • You have breast cancer.

Before you start, consult your doctor:

  • If you take birth control pills.
  • If you have diabetes.
  • If you have heart disease.
  • If you have epilepsy.
  • If you have kidney disease.
  • If you have liver disease.
  • If you have migraine headaches.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Risk to unborn child outweighs drug benefits. Don't use. Stop if you get pregnant.

Unknown whether medicine filters into milk. Consult doctor.

Infants & children:
Not recommended.

Prolonged use:

  • Required for full effect. Don't discontinue without consulting doctor.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check liver function, mammogram.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

Don't discontinue without consulting doctor. Menstrual periods may be absent for 2 to 3 months after discontinuation.


  • May alter blood-sugar levels in diabetic persons.
  • May interfere with the accuracy of some medical tests.

Possible Interaction with Other Drugs

------------------------ -----------------------
Anticoagulants, Increased anti-
oral* coagulant effect.
Antidiabetic agents, Decreased anti-
oral* diabetic effect.
Cyclosporine Increased risk of kidney damage.
Insulin Decreased insulin effect.

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Excessive nervous system
depression. Avoid.
Caffeine. Rapid, irregular heartbeat. Avoid.
Cocaine: May interfere with expected action
of danazol. Avoid.
Foods: No problems expected.
Marijuana: May interfere with expected action
of danazol. Avoid.
Tobacco: Rapid, irregular heartbeat. Avoid.
Increased leg cramps.

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