DANAZOL

Brand & Generic Names

Cyclomen

Danocrine

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? No
• Drug class: Gonadotropin inhibitor

Uses

Treatment of endometriosis, fibrocystic breast disease, angioneurotic edema except in pregnant women, gynecomastia, infertility, excessive menstruation, precocious puberty.

Dosage & Usage Information

How to take:
Capsule--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, open capsule and take with liquid or food.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember (don't double dose).

What drug does:
Partially prevents output of pituitary follicle-stimulating hormone and lutenizing hormone reducing estrogen production.

Time lapse before drug works:
2 to 3 months to treat endometriosis.
1 to 2 months to treat other disorders.

Don't take with:
Birth control pills.
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
None expected.

WHAT TO DO:

Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects

Life-threatening:

None expected.

Common:

Menstrual irregularities.

Infrequent:

• Unnatural hair growth in women, nosebleeds, bleeding gums, sore throat and chills.
• Dizziness; deepened voice; hoarseness; flushed or red skin; muscle cramps; enlarged clitoris; decreased testicle size; vaginal burning, itching; swollen feet; decreased breast size, increased or decreased sex drive.
• Headache, acne, weight gain, vision changes.

Rare:

Jaundice, flushing, sweating, vaginitis, rash, nausea, vomiting, constipation, abdominal pain.

Warnings & Precautions

Don't take if:

• You become pregnant.
• You have breast cancer.

Before you start, consult your doctor:

• If you take birth control pills.
• If you have diabetes.
• If you have heart disease.
• If you have epilepsy.
• If you have kidney disease.
• If you have liver disease.
• If you have migraine headaches.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use. Stop if you get pregnant.

Breast-feeding:
Unknown whether medicine filters into milk. Consult doctor.

Infants & children:
Not recommended.

Prolonged use:

• Required for full effect. Don't discontinue without consulting doctor.
• Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check liver function, mammogram.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

Discontinuing:
Don't discontinue without consulting doctor. Menstrual periods may be absent for 2 to 3 months after discontinuation.

Others:

• May alter blood-sugar levels in diabetic persons.
• May interfere with the accuracy of some medical tests.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Anticoagulants,	Increased anti-
oral*	coagulant effect.
Antidiabetic agents,	Decreased anti-
oral*	diabetic effect.
Cyclosporine	Increased risk of kidney damage.
Insulin	Decreased insulin effect.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Excessive nervous system
	depression. Avoid.
Caffeine.	Rapid, irregular heartbeat. Avoid.
Cocaine:	May interfere with expected action
	of danazol. Avoid.
Foods:	No problems expected.
Marijuana:	May interfere with expected action
	of danazol. Avoid.
Tobacco:	Rapid, irregular heartbeat. Avoid.
	Increased leg cramps.