Brand & Generic Names
- Habit forming? No
- Prescription needed? Yes
- Available as generic? No
- Drug class: Immunosuppressant, antineoplastic
- Treatment for cancer.
- Treatment for severe rheumatoid arthritis.
- Treatment for blood vessel disease.
- Treatment for skin disease.
Dosage & Usage Information
How to take:
Tablet or liquid--Swallow with liquid. If you can't swallow
whole, crumble tablet and take with liquid or food.
When to take:
Works best if taken first thing in morning. However, may take
with food to lessen stomach irritation. Don't take at bedtime.
If you forget a dose:
Take as soon as you remember up to 12
hours late. If more than 12 hours, wait for next scheduled dose
(don't double this dose).
What drug does:
Kills cancer cells.
Suppresses spread of cancer cells.
Suppresses immune system.
Time lapse before drug works:
7 to 10 days continual use.
Don't take with:
Any other medicine without consulting your doctor or pharmacist.
Bloody urine, water retention, weight gain, severe
WHAT TO DO:
Overdose unlikely to threaten life. If person takes much larger
amount than prescribed, call doctor, poison-control center or
hospital emergency room for instructions.
Possible Adverse Reactions or Side Effects
Hives, rash, intense Seek emergency
itching, faintness treatment immediately.
soon after a dose
- Sore throat, fever.
- Dark skin, nails;
loss; vomiting; missed
- Rash, hives, itch;
shortness of breath;
cough; blood in urine,
painful urination; pain
in side; bleeding,
foot or ankle swelling.
- Confusion, agitation,
flushed face, stomach
pain, joint pain,
- Mouth, lip sores;
- Blurred vision,
Warnings & Precautions
Don't take if:
- You are allergic to any alkylating agent.
- You have an infection.
- You have bloody urine.
- You will have surgery within 2 months, including dental
surgery, requiring general or spinal anesthesia.
Before you start, consult your doctor:
- If you have impaired liver or kidney function.
- If you have impaired bone marrow or blood cell production.
- If you have had chemotherapy or X-ray therapy.
- If you have taken cortisone drugs in the past year.
Over age 60:
Adverse reactions and side effects may be more frequent and
severe than in younger persons. To reduce risk of chemical
bladder inflammation, drink 8 to 10 glasses of water daily.
Risk to unborn child outweighs drug benefits. Don't use.
Drug passes into milk. Avoid drug or discontinue nursing until
you finish medicine. Consult doctor for advice on maintaining
Infants & children:
Use only under medical supervision.
- Development of fibrous lung tissue.
- Possible jaundice.
- Swelling of feet, lower legs.
- Infertility in men.
- Talk to your doctor about the need for follow-up medical
examinations or laboratory studies to check complete blood
counts (white blood cell count, platelet count, red blood cell
count, hemoglobin, hematocrit), urine, liver function.
Skin & sunlight:
No problems expected.
Driving, piloting or hazardous work:
Avoid if you feel dizzy or have blurred vision. Otherwise, no
Don't discontinue without consulting doctor. Dose may require
gradual reduction if you have taken drug for a long time. Doses
of other drugs may also require adjustment.
- Frequently causes hair loss. After treatment ends, hair should
- Avoid vaccinations.
Possible Interaction with Other Drugs
|Allopurinol or other
|medicines to treat gout
||decreased anti-gout effect.
||Increased bone marrow depressant
||Toxic effect on bone marrow.
||May increase risk of infection.
||Possible decreased digoxin
||Increased risk of infection.
||Increased insulin effect.
||Increased risk of bone marrow
||Increased heart and kidney damage.
||Increased cyclophosphamide effect.
||Increased blood uric acid.
||Increased risk of toxicity to bone
Possible Interaction with Other Substances
||No problems expected.
||No problems expected. Drink at
||least 2 quarts fluid every day.
||Increased danger of brain damage.
||Increased impairment of immunity.