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Brand & Generic Names


Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Immunosuppressant, antineoplastic


  • Treatment for cancer.
  • Treatment for severe rheumatoid arthritis.
  • Treatment for blood vessel disease.
  • Treatment for skin disease.

Dosage & Usage Information

How to take:
Tablet or liquid--Swallow with liquid. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
Works best if taken first thing in morning. However, may take with food to lessen stomach irritation. Don't take at bedtime.

If you forget a dose:
Take as soon as you remember up to 12 hours late. If more than 12 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Kills cancer cells.
Suppresses spread of cancer cells.
Suppresses immune system.

Time lapse before drug works:
7 to 10 days continual use.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Bloody urine, water retention, weight gain, severe infection.


    Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects


    Hives, rash, intense Seek emergency itching, faintness treatment immediately. soon after a dose (anaphylaxis).


  • Sore throat, fever.
  • Dark skin, nails; nausea; appetite loss; vomiting; missed menstrual period.


  • Rash, hives, itch; shortness of breath; rapid heartbeat; cough; blood in urine, painful urination; pain in side; bleeding, bruising; increased sweating; hoarseness; foot or ankle swelling.
  • Confusion, agitation, headache, dizziness, flushed face, stomach pain, joint pain, fatigue, weakness, diarrhea.


  • Mouth, lip sores; black stool; unusual thirst; jaundice.
  • Blurred vision, increased urination, hair loss.

Warnings & Precautions

Don't take if:

  • You are allergic to any alkylating agent.
  • You have an infection.
  • You have bloody urine.
  • You will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Before you start, consult your doctor:

  • If you have impaired liver or kidney function.
  • If you have impaired bone marrow or blood cell production.
  • If you have had chemotherapy or X-ray therapy.
  • If you have taken cortisone drugs in the past year.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons. To reduce risk of chemical bladder inflammation, drink 8 to 10 glasses of water daily.

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Use only under medical supervision.

Prolonged use:

  • Development of fibrous lung tissue.
  • Possible jaundice.
  • Swelling of feet, lower legs.
  • Cancer.
  • Infertility in men.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check complete blood counts (white blood cell count, platelet count, red blood cell count, hemoglobin, hematocrit), urine, liver function.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Avoid if you feel dizzy or have blurred vision. Otherwise, no problems expected.

Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.


  • Frequently causes hair loss. After treatment ends, hair should grow back.
  • Avoid vaccinations.

Possible Interaction with Other Drugs

------------------------ -----------------------
Allopurinol or other Possible anemia;
medicines to treat gout decreased anti-gout effect.
Antidiabetics*, Increased antidiabetic
oral effect.
Bone marrow Increased bone marrow depressant
depressants*, other effect.
Clozapine Toxic effect on bone marrow.
Cyclosporine May increase risk of infection.
Digoxin Possible decreased digoxin
Immunosuppressants,* other Increased risk of infection.
Insulin Increased insulin effect.
Levamisole Increased risk of bone marrow
Lovastatin Increased heart and kidney damage.
Phenobarbital Increased cyclophosphamide effect.
Probenecid Increased blood uric acid.
Tiopronin Increased risk of toxicity to bone

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: No problems expected.
Beverages: No problems expected. Drink at
least 2 quarts fluid every day.
Cocaine: Increased danger of brain damage.
Foods: None expected.
Marijuana: Increased impairment of immunity.
Tobacco: None expected.

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