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Brand & Generic Names

Cortone Cortone Acetate

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? Yes
  • Drug class: Cortisone drug (adrenal corticosteroid)


  • Reduces inflammation caused by many different medical problems.
  • Treatment for some allergic diseases, blood disorders, kidney diseases, asthma and emphysema.
  • Replaces corticosteroid deficiencies.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food.

When to take:
At the same times each day. Take once-a-day or once-every-other- day doses in mornings.

If you forget a dose:
Several-doses-per-day prescription--Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).
Once-a-day dose or less--Wait for next dose. Double this dose.

What drug does:
Decreases inflammatory responses.
Replaces cortisone in patients with adrenal insufficiency.

Time lapse before drug works:
2 to 4 days.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Headache, convulsions, fluid retention, heart failure.


  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects


    Hives, rash, intense Seek emergency itching, faintness treatment immediately. soon after a dose (anaphylaxis).


    Acne, thirst, nausea, indigestion, vomiting, poor wound healing.


  • Bloody or black, tarry stool.
  • Blurred vision; halos around lights; sore throat, fever; muscle cramps; swollen legs, feet.
  • Mood changes, insomnia, fatigue, restlessness, frequent urination, weight gain, round face, weakness, irregular menstrual periods.


  • Irregular heartbeat.
  • Rash, hallucinations, thrombophlebitis, pancreatitis, numbness or tingling in hands or feet, convulsions.

Warnings & Precautions

Don't take if:

  • You are allergic to any cortisone drug.
  • You have tuberculosis or fungus infection.
  • You have herpes infection of eyes, lips or genitals.

Before you start, consult your doctor:

  • If you have had tuberculosis.
  • If you have congestive heart failure.
  • If you have diabetes, peptic ulcer, glaucoma, underactive thyroid, high blood pressure, myasthenia gravis, blood clots in legs or lungs.

Over age 60:

  • Adverse reactions and side effects may be more frequent and severe than in younger persons.
  • Likely to aggravate edema, diabetes or ulcers.
  • Likely to cause cataracts and osteoporosis (softening of the bones).

Risk to unborn child outweighs drug benefits. Don't use.

Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Use only under medical supervision.

Prolonged use:

  • Retards growth in children.
  • Possible glaucoma, cataracts, diabetes, fragile bones and thin skin.
  • Functional dependence.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check blood sugar, eyes, serum electrolytes, stools for blood.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.


  • Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear.
  • Drug affects your response to surgery, illness, injury or stress for 2 years after discontinuing. Tell anyone who takes medical care of you within 2 years about drug.


  • Avoid immunizations if possible.
  • Your resistance to infection is less while taking this medicine.
  • Advise any doctor or dentist whom you consult that you take this medicine.
  • Those who have inactive or "cured" tuberculosis may be subjected to a possible recurrence of active tuberculosis.
  • Children who must take cortisone drugs may grow less well.

Possible Interaction with Other Drugs

------------------------ -----------------------
Amphotericin B Potassium depletion.
Anticholinergics* Possible glaucoma.
Anticoagulants*, Decreased anti-
oral coagulant effect.
Anticonvulsants, Decreased
hydantoin* cortisone effect.
Antidiabetics*, Decreased anti-
oral diabetic effect.
Antihistamines* Decreased cortisone effect.
Aspirin Increased cortisone effect.
Attenuated virus Possible viral
vaccines* infection.
Barbiturates* Decreased cortisone effect.
Chloral hydrate Decreased cortisone effect.
Chlorthalidone Potassium depletion.
Cholinergics* Decreased cholinergic effect.
Cholestyramine Decreased cortisone absorption
Colestipol Decreased cortisone abosrption
Contraceptives*, Increased
oral cortisone effect.
Cyclosporine Increased risk of infection.
Diclofenac Increased risk of stomach ulcer.
Digitalis Dangerous potassium
preparations* depletion. Possible digitalis
Diuretics, thiazide* Potassium depletion.
Ephedrine Decreased cortisone effect.
Estrogens* Increased cortisone effect.
Ethacrynic acid Potassium depletion.
Furosemide Potassium depletion.
Glutethimide Decreased cortisone effect.
Indapamide Possible excessive potassium loss,
causing dangerous heartbeat
Indomethacin Increased cortisone effect.
Insulin Decreased insulin effect.
Isoniazid Decreased isoniazid effect.
Ketoprofen Increased risk of stomach ulcer and
Mitotane Decreased cortisone effect.
Non-steroidal Increased risk of ulcers,
anti-inflammatory increased cortisone effect.
Oxyphenbutazone Possible ulcers.
Phenobarbital Decreased cortisone effect.
Phenylbutazone Possible ulcers.
Potassium Decreased potassium
supplements* effect.
Rifampin Decreased cortisone effect.
Salicylates* Decreased salicylate effect.
Sodium bicarbonate Sodium overload.
Sympathomimetics* Possible glaucoma.
Theophylline Possible increased theophylline
Vaccines, other Increased risk of developing disease
immunizations vaccine is for or decreased vaccine

Possible Interaction with Other Substances

--------------- ---------------
Alcohol: Risk of stomach ulcers.
Beverages: No proven problems.
Cocaine: Overstimulation. Avoid.
Foods: No proven problems.
Marijuana: Decreased immunity.
Tobacco: Increased cortisone effect.
Possible toxicity.

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