CLIDINIUM

Brand & Generic Names

Apo-Chlorax	Lidox
Clindex	Lodoxide
Clinoxide	Quarzan
Corium	Zebrax
Librax

Basic Information

• Habit forming? No
• Prescription needed? Low strength: No High strength: Yes
• Available as generic? No
• Drug class: Antispasmodic, anticholinergic

Uses

Reduces spasms of digestive system, bladder and urethra.

Dosage & Usage Information

How to take:
Capsule--Swallow with liquid or food to lessen stomach irritation.

When to take:
30 minutes before meals (unless directed otherwise by doctor).

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Blocks nerve impulses at parasympathetic nerve endings, preventing muscle contractions and gland secretions of organs involved.

Time lapse before drug works:
15 to 30 minutes.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
Dilated pupils, rapid pulse and breathing, dizziness, fever, hallucinations, confusion, slurred speech, agitation, flushed face, convulsions, coma.

WHAT TO DO:

• Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
• See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

In case of overdose, see Overdose section.

Common:

• Confusion, delirium, rapid heartbeat.
• Nausea, vomiting, decreased sweating.
• Constipation.
• Dryness in ears, nose, throat, mouth.

Infrequent:

• Nasal congestion, altered taste, difficult urination, headache, impotence.
• Lightheadedness.

Rare:

Rash or hives, eye pain, blurred vision.

Warnings & Precautions

Don't take if:

• You are allergic to any anticholinergic.
• You have trouble with stomach bloating.
• You have difficulty emptying your bladder completely (enlarged prostate).
• You have narrow-angle glaucoma.
• You have severe ulcerative colitis.

Before you start, consult your doctor:

• If you have open-angle glaucoma.
• If you have angina, chronic bronchitis or asthma, kidney or thyroid disease, hiatal hernia, liver disease, enlarged prostate, myasthenia gravis, peptic ulcer.
• If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Studies inconclusive on harm to unborn child. Animal studies show fetal abnormalities. Decide with your doctor whether drug benefits justify risk to unborn child.

Breast-feeding:
Drug passes into milk and decreases milk flow. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Use only under medical supervision.

Prolonged use:
Chronic constipation, possible fecal impaction. Consult doctor immediately.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics, or mind-altering drugs.

Discontinuing:
May be unnecessary to finish medicine. Follow doctor's instructions.

Others:
Advise any doctor or dentist whom you consult that you take this medicine.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Amantadine	Increased clidinium effect.
Antacids*	Decreased clidinium effect.
Anticholinergics,	Increased clidinium
other*	effect.
Antidepressants,	Increased clidinium
tricyclic (TCA)*	effect. Increased sedation.
Antidiarrheals*	Increased clidinium effect.
Antihistamines*	Increased clidinium effect.
Attapulgite	Decreased clidinium effect.
Haloperidol	Increased internal-eye pressure.
Ketoconazole	Decreased ketoconazole effect.
MAO inhibitors*	Increased clidinium effect.
Meperidine	Increased clidinium effect.
Methylphenidate	Increased clidinium effect.
Molindone	Increased anticholinergic effect.
Nitrates*	Increased internal-eye pressure.
Nizatidine	Increased nizatidine effect.
Orphenadrine	Increased clidinium effect.
Pilocarpine	Loss of pilocarpine effect in
	glaucoma treatment.
Potassium	Possible intestinal
supplements*	ulcers with oral potassium tablets.
Tranquilizers*	Decreased clidinium effect.
Vitamin C	Decreased clidinium effect. Avoid
	large doses of vitamin C.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	None expected.
Beverages:	None expected.
Cocaine:	Excessively rapid heartbeat. Avoid.
Foods:	None expected.
Marijuana:	Drowsiness and dry mouth.
Tobacco:	None expected.